iPTMnet Report for Q96Q15 (SMG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96Q15 / SMG1_HUMAN
Protein Name Serine/threonine-protein kinase SMG1
Gene Name Name: SMG1
Synonyms:ATX;
Organism Homo sapiens (Human)

PRO ID PR:Q96Q15
DAG View
PRO Name serine/threonine-protein kinase SMG1 (human)
Definition A serine/threonine-protein kinase SMG1 that is encoded in the genome of human.
Short Label hSMG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96Q15 (SMG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T19 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
K43 Methylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
R50 Methylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus
S103 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
T130 Phosphorylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
Y143 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus
T157 Phosphorylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K173 Acetylation PhosphoSitePlus   UniProt 19608861
K173 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
Y252 Phosphorylation PhosphoSitePlus
T256 Phosphorylation PhosphoSitePlus
Y257 Phosphorylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
C475 Methylation IEDB 31844290
K529 Ubiquitination PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
Y549 Phosphorylation PhosphoSitePlus
K598 Ubiquitination PhosphoSitePlus
K608 Ubiquitination PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
Y662 Phosphorylation IEDB 35494241
S708 Phosphorylation PhosphoSitePlus
S753 Phosphorylation PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
K879 Ubiquitination PhosphoSitePlus
T900 Phosphorylation PhosphoSitePlus
Y995 Phosphorylation PhosphoSitePlus
Y998 Phosphorylation PhosphoSitePlus
T1006 Phosphorylation PhosphoSitePlus
S1007 Phosphorylation PhosphoSitePlus
T1047 Phosphorylation PhosphoSitePlus
K1174 Ubiquitination PhosphoSitePlus
K1215 Ubiquitination PhosphoSitePlus
S1218 Phosphorylation PhosphoSitePlus
S1221 Phosphorylation PhosphoSitePlus
K1232 Ubiquitination PhosphoSitePlus
K1241 Ubiquitination PhosphoSitePlus
K1265 Ubiquitination PhosphoSitePlus
K1287 Acetylation PhosphoSitePlus
K1287 Ubiquitination PhosphoSitePlus
K1411 Ubiquitination PhosphoSitePlus
K1455 Ubiquitination PhosphoSitePlus
K1467 Ubiquitination PhosphoSitePlus
K1468 Ubiquitination PhosphoSitePlus
K1478 Ubiquitination PhosphoSitePlus
K1513 Acetylation PhosphoSitePlus
K1516 Acetylation PhosphoSitePlus
K1516 Ubiquitination PhosphoSitePlus
Y1519 Phosphorylation PhosphoSitePlus
T1527 Phosphorylation PhosphoSitePlus
K1544 Ubiquitination PhosphoSitePlus
K1632 Ubiquitination PhosphoSitePlus
S1638 Phosphorylation PhosphoSitePlus
K1650 Ubiquitination PhosphoSitePlus
T1660 Phosphorylation PhosphoSitePlus
K1666 Ubiquitination PhosphoSitePlus
T1789 Phosphorylation PhosphoSitePlus
K1798 Ubiquitination PhosphoSitePlus
S1897 Phosphorylation PhosphoSitePlus
S1903 Phosphorylation PhosphoSitePlus
S1907 Phosphorylation PhosphoSitePlus
S1910 Phosphorylation PhosphoSitePlus
S1917 Phosphorylation PhosphoSitePlus
C1929 Methylation IEDB 31844290
K1989 Ubiquitination PhosphoSitePlus
K2038 Ubiquitination PhosphoSitePlus
K2063 Ubiquitination PhosphoSitePlus
S2087 Phosphorylation IEDB   PhosphoSitePlus 27920218
K2138 Acetylation PhosphoSitePlus
K2139 Acetylation PhosphoSitePlus
K2139 Ubiquitination PhosphoSitePlus
K2148 Acetylation PhosphoSitePlus
S2149 Phosphorylation PhosphoSitePlus
Y2150 Phosphorylation PhosphoSitePlus
Y2152 Phosphorylation PhosphoSitePlus
Y2193 Phosphorylation PhosphoSitePlus
K2232 Ubiquitination PhosphoSitePlus
T2239 Phosphorylation PhosphoSitePlus
Y2253 Phosphorylation PhosphoSitePlus
Y2254 Phosphorylation PhosphoSitePlus
S2255 Phosphorylation PhosphoSitePlus
K2256 Ubiquitination PhosphoSitePlus
S2267 Phosphorylation PhosphoSitePlus
K2370 Ubiquitination PhosphoSitePlus
K2471 Ubiquitination PhosphoSitePlus
K2507 Ubiquitination PhosphoSitePlus
K2511 Ubiquitination PhosphoSitePlus
Y2536 Phosphorylation PhosphoSitePlus
S2537 Phosphorylation PhosphoSitePlus
K2658 Ubiquitination PhosphoSitePlus
Y2713 Phosphorylation PhosphoSitePlus
K2729 Ubiquitination PhosphoSitePlus
T2776 Phosphorylation PhosphoSitePlus
C2872 Methylation IEDB 31844290
S2955 Phosphorylation PhosphoSitePlus
K3030 Ubiquitination PhosphoSitePlus
K3140 Ubiquitination PhosphoSitePlus
T3181 Phosphorylation PhosphoSitePlus
T3245 Phosphorylation PhosphoSitePlus
K3426 Ubiquitination PhosphoSitePlus
S3544 Phosphorylation PhosphoSitePlus
T3546 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
T3550 Phosphorylation PhosphoSitePlus   UniProt 17525332, 23186163
S3556 Phosphorylation PhosphoSitePlus   UniProt 17525332, 23186163
T3569 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S3570 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
T3573 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S3576 Phosphorylation PhosphoSitePlus
T3577 Phosphorylation PhosphoSitePlus
S3584 O-Glycosylation GlyGen 30379171
S3588 Phosphorylation PhosphoSitePlus
K3619 Methylation PhosphoSitePlus
S3632 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T19 Phosphorylation HPRD 20068231
S115 Phosphorylation HPRD 20068231
T1527 Phosphorylation HPRD 19413330
T3235 Phosphorylation HPRD 20068231
T3245 Phosphorylation HPRD 18452278
S3256 Phosphorylation HPRD 20068231
T3550 Phosphorylation HPRD 17525332, 18077418
S3556 Phosphorylation HPRD 17525332, 18077418
T3569 Phosphorylation HPRD 17081983, 20068231
S3570 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
T3573 Phosphorylation HPRD 19413330, 18691976, 19664994, ...18452278, 19651622, 18669648, 20068231
S3576 Phosphorylation HPRD 19413330, 19651622, 18669648, ...17081983, 20068231
T3577 Phosphorylation HPRD 19413330, 17081983, 20068231


Q96Q15 (SMG1) as PTM Enzyme



Substrate Site Score Source PMID
P04637 (TP53) S15 PhosphoSitePlus   Signor 15175154, 18332866
Q92900 (UPF1) T28 PhosphoSitePlus   Signor 21965535, 23356578
Q92900 (UPF1) S1084 PhosphoSitePlus 11544179
Q92900 (UPF1) S1089 PhosphoSitePlus   Signor 23356578, 11544179
Q92900 (UPF1) S1107 PhosphoSitePlus   Signor 21965535, 23356578, 11544179
Q92900 (UPF1) S1127 PhosphoSitePlus 11544179


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 T34 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R50 K50 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S103 L103 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S140 L140 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S144 C144 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
C475 R475 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K598 M598 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S753 C753 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S1007 L1007 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T1527 I1527 Biomuta DOID:363 / uterine cancer [ icgc ]
S1907 F1907 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1989 N1989 Biomuta DOID:1612 / breast cancer [ cosmic ]
K2063 E2063 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
Y2536 H2536 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S2537 F2537 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K3140 N3140 Biomuta DOID:3571 / liver cancer [ cosmic ]
S3256 I3256 Biomuta DOID:4159 / skin cancer [ cosmic ]
K3426 T3426 Biomuta DOID:363 / uterine cancer [ icgc ]
T3569 I3569 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T3569 A3569 Biomuta DOID:1324 / lung cancer [ cosmic ]
S3570 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K3619 R3619 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S3632 L3632 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]