iPTMnet Report for Q96PY6 (NEK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96PY6 / NEK1_HUMAN
Protein Name Serine/threonine-protein kinase Nek1
Gene Name Name: NEK1
Synonyms:KIAA1901;
Organism Homo sapiens (Human)

PRO ID PR:Q96PY6
DAG View
PRO Name serine/threonine-protein kinase Nek1 (human)
Definition A serine/threonine-protein kinase Nek1 that is encoded in the genome of human.
Short Label hNEK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96PY6 (NEK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus   RLIMS-P 28426283, 30737777, 32905878
S155 Phosphorylation PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus   UniProt 23186163
T162 Phosphorylation RLIMS-P 28710492
S207 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
Y315 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
K322 Acetylation PhosphoSitePlus
T344 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T351 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus   UniProt 19369195
S418 Phosphorylation PhosphoSitePlus   UniProt 19369195
S428 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
S435 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
R472 Methylation PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
Y557 Phosphorylation PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
S653 Phosphorylation PhosphoSitePlus   UniProt 19369195
T661 Phosphorylation PhosphoSitePlus   UniProt 23186163
S664 Phosphorylation PhosphoSitePlus   UniProt 23186163
S675 Phosphorylation PhosphoSitePlus
T735 Phosphorylation PhosphoSitePlus
S798 Phosphorylation PhosphoSitePlus   UniProt 19369195
K805 Methylation PhosphoSitePlus
S806 Phosphorylation PhosphoSitePlus
T808 Phosphorylation PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus   UniProt 19369195
S837 Phosphorylation PhosphoSitePlus
T848 Phosphorylation PhosphoSitePlus
S868 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
S874 Phosphorylation PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
S881 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
S885 Phosphorylation PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
S1004 Phosphorylation PhosphoSitePlus
S1008 Phosphorylation PhosphoSitePlus
S1030 Phosphorylation PhosphoSitePlus
T1050 Phosphorylation PhosphoSitePlus
S1052 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S1092 Phosphorylation PhosphoSitePlus
Y1125 Phosphorylation PhosphoSitePlus
S1126 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1225 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T344 Phosphorylation HPRD 18691976, 18669648
S653 Phosphorylation HPRD 18691976
T661 Phosphorylation HPRD 18691976
S664 Phosphorylation HPRD 18691976, 15345747
S837 Phosphorylation HPRD 18691976
S881 Phosphorylation HPRD 19413330
T1050 Phosphorylation HPRD 19664994
S1052 Phosphorylation HPRD 18691976
S1126 Phosphorylation HPRD 19413330, 18691976, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S572 Phosphorylation PhosphoSitePlus


Q96PY6 (NEK1) as PTM Enzyme



Substrate Site Score Source PMID
O14777 (NDC80) S165 PhosphoSitePlus 12386167
P21796 (VDAC1) S193 PhosphoSitePlus   Signor 20230784, 19158487
P40337 (VHL) T100 PhosphoSitePlus 23255108
P40337 (VHL) T105 PhosphoSitePlus 23255108
P40337 (VHL) Y112 PhosphoSitePlus 23255108
P40337 (VHL) S168 PhosphoSitePlus 23255108
P40337 (VHL) Y175 PhosphoSitePlus 23255108
P40337 (VHL) S183 PhosphoSitePlus 23255108
P40337 (VHL) T202 PhosphoSitePlus 23255108


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K130 N130 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K138 R138 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y315 C315 Biomuta DOID:3571 / liver cancer [ cosmic ]
S428 I428 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S428 T428 Biomuta DOID:1324 / lung cancer [ cosmic ]
S435 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y470 H470 Biomuta DOID:184 / bone cancer [ cosmic ]
R472 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S607 P607 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S868 Y868 Biomuta DOID:1319 / brain cancer [ icgc ]
S1052 L1052 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1052 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1125 C1125 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]