iPTMnet Report for Q96PY5 (FMNL2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96PY5 / FMNL2_HUMAN
Protein Name Formin-like protein 2
Gene Name Name: FMNL2
Synonyms:FHOD2,KIAA1902;
Organism Homo sapiens (Human)

PRO ID PR:Q96PY5
DAG View
PRO Name formin-like protein 2 (human)
Definition A formin-like protein 2 that is encoded in the genome of human.
Short Label hFMNL2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96PY5 (FMNL2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 20213681
Y55 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
S171 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 31751425, 25963737, 18669648, ...17081983
S179 Phosphorylation PhosphoSitePlus
S183 O-Glycosylation GlyGen 29237092
S183 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus   UniProt 23186163
S190 O-Glycosylation GlyGen 29237092
S190 Phosphorylation PhosphoSitePlus
Y200 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
S212 O-Glycosylation GlyGen 30379171
Y352 Phosphorylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
Y441 Phosphorylation PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
K453 Methylation PhosphoSitePlus
K456 Methylation PhosphoSitePlus
K458 Methylation PhosphoSitePlus
S466 Phosphorylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
T727 Phosphorylation PhosphoSitePlus
S763 Phosphorylation PhosphoSitePlus
R767 Methylation PhosphoSitePlus
T799 Phosphorylation PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus
Y841 Phosphorylation PhosphoSitePlus
T854 Phosphorylation PhosphoSitePlus
T913 O-Glycosylation GlyGen 30379171
S1016 Phosphorylation PhosphoSitePlus   Signor 29930204
S1016 Phosphorylation P06493 (CDK1) Signor 29930204
S1018 Phosphorylation PhosphoSitePlus
S1072 Phosphorylation PhosphoSitePlus   RLIMS-P 31751425, 26256210
Site PTM Type PTM Enzyme Score Source PMID
Y55 Phosphorylation HPRD 20068231
S171 Phosphorylation HPRD 18578522, 18707149, 18669648, ...20068231, 17081983
S179 Phosphorylation HPRD 20068231
S183 Phosphorylation HPRD 20068231
S1016 Phosphorylation HPRD 18691976, 18669648, 17081983, ...20068231
S1018 Phosphorylation HPRD 18669648, 17081983
S1072 Phosphorylation PhosphoSitePlus 26256210
S1072 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 26256210


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q16658 (FSCN1) S39 Q96PY5 (FMNL2) increased_association eFIP 32294157


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y55 H55 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1016 F1016 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1016 P1016 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S1018 F1018 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]