iPTMnet Report for Q96PV0 (SYNGAP1)
Protein Information
| UniProt AC / UniProt ID | Q96PV0 / SYGP1_HUMAN |
| Protein Name | Ras/Rap GTPase-activating protein SynGAP |
| Gene Name | Name: SYNGAP1 Synonyms:KIAA1938; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q96PV0 |
| PRO Name | Ras/Rap GTPase-activating protein SynGAP (human) |
| Definition | A Ras/Rap GTPase-activating protein SynGAP that is encoded in the genome of human. |
| Short Label | hSYNGAP1 |
| Category | organism-gene |
DAG ViewQ96PV0 (SYNGAP1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S87 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K145 | Acetylation | score1 | PhosphoSitePlus | |||
| K178 | Methylation | score1 | PhosphoSitePlus | |||
| Y291 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S449 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y682 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S809 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| T822 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S840 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S840 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S842 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 35624196 | ||
| S858 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S859 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S873 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| T878 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S892 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S898 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| T900 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S907 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T912 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| T912 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T913 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| T913 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S983 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S1005 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S1079 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S1087 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S1114 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1132 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1134 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| T1147 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| S1151 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1159 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 | ||
| Y1183 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1186 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1190 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1206 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S1261 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1310 | O-Glycosylation | score3 | GlyGen | 35637289, 28657654 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S766 | Phosphorylation | score1 | HPRD | 14970204 | ||
| S771 | Phosphorylation | score1 | HPRD | 14970204 | ||
| S779 | Phosphorylation | score1 | HPRD | 14970204 | ||
| S780 | Phosphorylation | score1 | HPRD | 14970204 | ||
| S1073 | Phosphorylation | Q9UQM7 (CAMK2A) | score2 | HPRD | 15358237, 14970204 | |
| T1077 | Phosphorylation | Q9UQM7 (CAMK2A) | score1 | HPRD | 15358237 | |
| S1079 | Phosphorylation | score1 | HPRD | 14970204 | ||
| S1138 | Phosphorylation | Q9UQM7 (CAMK2A) | score1 | HPRD | 14970204 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S1114 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1132 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y291 | S291 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
| S873 | R873 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S898 | F898 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T900 | M900 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] | |
| S1151 | T1151 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| Y1183 | * | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S1186 | L1186 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| T1310 | M1310 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
