Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96PV0 / SYGP1_HUMAN
Protein Name Ras/Rap GTPase-activating protein SynGAP
Gene Name Name: SYNGAP1
Synonyms:KIAA1938;
Organism Homo sapiens (Human)

PRO ID PR:Q96PV0
DAG View
PRO Name Ras/Rap GTPase-activating protein SynGAP (human)
Definition A Ras/Rap GTPase-activating protein SynGAP that is encoded in the genome of human.
Short Label hSYNGAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96PV0 (SYNGAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S87 Phosphorylation PhosphoSitePlus
K145 Acetylation PhosphoSitePlus
K178 Methylation PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
Y682 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S842 Phosphorylation PhosphoSitePlus
S907 Phosphorylation PhosphoSitePlus
T912 Phosphorylation PhosphoSitePlus
T913 Phosphorylation PhosphoSitePlus
S1114 Phosphorylation PhosphoSitePlus
S1132 Phosphorylation PhosphoSitePlus
S1151 Phosphorylation PhosphoSitePlus
Y1183 Phosphorylation PhosphoSitePlus
S1184 Phosphorylation PhosphoSitePlus
S1186 Phosphorylation PhosphoSitePlus
S1190 Phosphorylation PhosphoSitePlus
K1206 Ubiquitination PhosphoSitePlus
S1261 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S766 Phosphorylation HPRD 14970204
S771 Phosphorylation HPRD 14970204
S779 Phosphorylation HPRD 14970204
S780 Phosphorylation HPRD 14970204
S1073 Phosphorylation Q9UQM7 (CAMK2A) HPRD 15358237, 14970204
T1077 Phosphorylation Q9UQM7 (CAMK2A) HPRD 15358237
S1079 Phosphorylation HPRD 14970204
S1138 Phosphorylation Q9UQM7 (CAMK2A) HPRD 14970204
Site PTM Type PTM Enzyme Score Source PMID
S1114 Phosphorylation PhosphoSitePlus
S1132 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y291 S291 Biomuta DOID:263 / kidney cancer [ tcga ]
S1073 C1073 Biomuta DOID:4362 / cervical cancer [ icgc ]
S1151 T1151 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1186 L1186 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]