iPTMnet Report for Q96PU5 (NEDD4L)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96PU5 / NED4L_HUMAN
Protein Name E3 ubiquitin-protein ligase NEDD4-like
Gene Name Name: NEDD4L
Synonyms:KIAA0439;
Organism Homo sapiens (Human)

PRO ID PR:Q96PU5
DAG View
PRO Name E3 ubiquitin-protein ligase NEDD4-like (human)
Definition An E3 ubiquitin-protein ligase NEDD4-like that is encoded in the genome of human.
Short Label hNEDD4L
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96PU5 (NEDD4L) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S13 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S256 O-Glycosylation GlyGen 34725712, 28657654, 30169966, ...29351928
S297 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
T302 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S303 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus   UniProt 23186163
T318 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S321 Phosphorylation PhosphoSitePlus
S327 Phosphorylation RLIMS-P 20730100, 24657276
S328 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
S342 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21852580, 16716084, 34294877, ...11742982, 20525693, 15140763, 12911626, 31320629, 19917253, 27932573, 20433953, 18669648, 17715136, 22301619, 15328345
S342 Phosphorylation O00141 (SGK1) neXtProt   PhosphoSitePlus   Signor 21852580, 15140763, 11742982, ...19917253, 22301619, 16716084
S342 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 15328345
T344 Phosphorylation PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
T367 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 20433953, 15328345, 15140763
T367 Phosphorylation O00141 (SGK1) PhosphoSitePlus 15140763
T367 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 15328345
T369 Phosphorylation PhosphoSitePlus
T375 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus   RLIMS-P 17715136
S446 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 27920218, 18669648, 19690332
S448 Phosphorylation IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21852580, 15328345, 34294877, ...15496163, 20433953, 15140763, 29505301, 31320629, 19917253, 27932573, 12911626, 18669648, 11742982, 22301619, 23186163, 15677482, 30784271, 16716084, 15044175
S448 Phosphorylation O00141 (SGK1) neXtProt   PhosphoSitePlus   Signor 21852580, 15677482, 15140763, ...11742982, 19917253, 22301619, 16716084
S448 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 15328345
S448 Phosphorylation Q96BR1 (SGK3) neXtProt 15044175, 15496163
S449 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20525693, 17081983
T451 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T453 O-Glycosylation GlyGen 34725712, 28657654, 30169966, ...29351928
T453 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
S464 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K471 Ubiquitination PhosphoSitePlus
T473 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus   UniProt 23186163
S479 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S483 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
Y485 Phosphorylation PhosphoSitePlus
S487 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983
K489 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
K572 Ubiquitination PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
Y660 Phosphorylation PhosphoSitePlus
Y680 Phosphorylation IEDB 31848261
S795 Phosphorylation PhosphoSitePlus
S867 Phosphorylation IEDB 32157095
C874 Methylation IEDB 31844290
T903 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T302 Phosphorylation HPRD 18669648
T318 Phosphorylation HPRD 18669648, 20068231
S340 Phosphorylation PhosphoSitePlus
S342 Phosphorylation HPRD   PhosphoSitePlus 12911626, 11742982
S342 Phosphorylation O00141 (SGK1) HPRD 12911626, 11742982
T344 Phosphorylation PhosphoSitePlus
S426 Phosphorylation HPRD 18691976, 20230923, 19664995, ...18452278, 19651622, 18669648, 20166139, 20068231
S428 Phosphorylation HPRD 19413330, 18691976, 20230923, ...18767875, 19664995, 11742982, 19651622, 12911626, 18669648, 20166139, 20068231
S428 Phosphorylation O00141 (SGK1) HPRD 19413330, 18691976, 20230923, ...18767875, 19664995, 11742982, 19651622, 12911626, 18669648, 20166139, 20068231
S429 Phosphorylation HPRD 18691976, 18669648, 19664995, ...20068231
T431 Phosphorylation HPRD 18669648
S444 Phosphorylation HPRD 18669648
T453 Phosphorylation HPRD 19651622
S455 Phosphorylation HPRD 19651622
S459 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S463 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S467 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96PU5 (NEDD4L) S448 Q6UUV7 (CRTC3) unknown eFIP 29505301
Phosphorylation Q96PU5 (NEDD4L) S448 P27348 (YWHAQ) unknown eFIP 34294877


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 A28 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S256 G256 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S256 R256 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S297 P297 Biomuta DOID:3571 / liver cancer [ cosmic ]
T302 S302 Biomuta DOID:1612 / breast cancer [ cosmic ]
S327 G327 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S327 N327 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S328 F328 Biomuta DOID:3571 / liver cancer [ cosmic ]
S340 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S342 I342 Biomuta DOID:1324 / lung cancer [ cosmic ]
S342 N342 Biomuta DOID:3571 / liver cancer [ cosmic ]
S365 L365 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
T369 M369 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T375 M375 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S428 P428 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S428 L428 Biomuta DOID:4159 / skin cancer [ cosmic ]
S428 G428 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S448 G448 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T453 I453 Biomuta DOID:4159 / skin cancer [ cosmic ]
S459 P459 Biomuta DOID:363 / uterine cancer [ icgc ]
T473 I473 Biomuta DOID:4159 / skin cancer [ cosmic ]
S479 P479 Biomuta DOID:363 / uterine cancer [ icgc ]
K521 N521 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K639 Q639 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y660 N660 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
Y680 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S867 F867 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]