iPTMnet Report for Q96PU4 (UHRF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96PU4 / UHRF2_HUMAN
Protein Name E3 ubiquitin-protein ligase UHRF2
Gene Name Name: UHRF2
Synonyms:NIRF,RNF107;
Organism Homo sapiens (Human)

PRO ID PR:Q96PU4
DAG View
PRO Name E3 ubiquitin-protein ligase UHRF2 (human)
Definition An E3 ubiquitin-protein ligase UHRF2 that is encoded in the genome of human.
Short Label hUHRF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96PU4 (UHRF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
C14 Methylation IEDB 31844290
K22 Ubiquitination PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K238 Sumoylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K401 Sumoylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
R428 Methylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
K575 Ubiquitination PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
Y588 Phosphorylation PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
Y641 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
S654 Phosphorylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
T661 Phosphorylation PhosphoSitePlus
T662 Phosphorylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
S667 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S673 Phosphorylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
C748 Methylation IEDB 31844290
Site PTM Type PTM Enzyme Score Source PMID
S667 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K322 N322 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K519 T519 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K575 E575 Biomuta DOID:4362 / cervical cancer [ icgc ]
Y584 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S667 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K679 T679 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]