Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96PQ1 / SIG12_HUMAN
Protein Name Sialic acid-binding Ig-like lectin 12 precursor
Gene Name Name: SIGLEC12
Synonyms:SIGLECL1,SLG;ORFNames:UNQ9215/PRO34042;
Organism Homo sapiens (Human)

PRO ID PR:Q96PQ1
DAG View
PRO Name sialic acid-binding Ig-like lectin 12 (human)
Definition A sialic acid-binding Ig-like lectin 12 that is encoded in the genome of human.
Short Label hSIGLEC12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96PQ1 (SIGLEC12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S107 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
T478 Phosphorylation PhosphoSitePlus
T488 Phosphorylation PhosphoSitePlus
Y494 Phosphorylation PhosphoSitePlus
Y588 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T216 Phosphorylation HPRD 18452278
T228 Phosphorylation HPRD 18452278
S234 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
T24 Phosphorylation PhosphoSitePlus
T98 Phosphorylation HPRD 18452278
T110 Phosphorylation HPRD 18452278
S116 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S107 R107 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
T216 S216 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T478 M478 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T478 A478 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T488 A488 Biomuta DOID:363 / uterine cancer [ tcga ]
Y494 S494 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y494 H494 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
Y588 C588 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:3571 / liver cancer [ icgc ]