iPTMnet Report for Q96PE2 (ARHGEF17)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96PE2 / ARHGH_HUMAN
Protein Name Rho guanine nucleotide exchange factor 17
Gene Name Name: ARHGEF17
Synonyms:KIAA0337,TEM4;
Organism Homo sapiens (Human)

PRO ID PR:Q96PE2
DAG View
PRO Name Rho guanine nucleotide exchange factor 17 (human)
Definition A Rho guanine nucleotide exchange factor 17 that is encoded in the genome of human.
Short Label hARHGEF17
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96PE2 (ARHGEF17) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
T35 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
R45 Methylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus   UniProt 24275569
T150 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
T170 Phosphorylation PhosphoSitePlus
R183 Methylation PhosphoSitePlus
T189 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
Y380 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
Y393 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus   UniProt 23186163
S418 Phosphorylation PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus   UniProt 23186163
R429 Methylation PhosphoSitePlus
R433 Methylation PhosphoSitePlus
S461 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S463 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S476 Phosphorylation phospho.ELM 15302935
S507 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S509 Phosphorylation HPRD   phospho.ELM 18669648
S527 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T530 Phosphorylation PhosphoSitePlus
K535 Acetylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus   UniProt 24275569
S566 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
S569 Phosphorylation PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus
T702 Phosphorylation neXtProt   PhosphoSitePlus 22028470
T702 Phosphorylation P28482 (MAPK1) neXtProt 22028470
S733 Phosphorylation PhosphoSitePlus
S735 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19691289
T751 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
S764 Phosphorylation HPRD   PhosphoSitePlus 20068231
S787 Phosphorylation PhosphoSitePlus
S790 Phosphorylation PhosphoSitePlus
T809 Phosphorylation PhosphoSitePlus
S827 Phosphorylation PhosphoSitePlus
S829 Phosphorylation PhosphoSitePlus
S885 Phosphorylation PhosphoSitePlus
T898 Phosphorylation PhosphoSitePlus
S914 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18212344
S930 Phosphorylation PhosphoSitePlus
S940 Phosphorylation PhosphoSitePlus
T944 Phosphorylation PhosphoSitePlus
S946 Phosphorylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
S1002 Phosphorylation PhosphoSitePlus
T1007 Phosphorylation PhosphoSitePlus
S1192 Phosphorylation PhosphoSitePlus
K1245 Ubiquitination PhosphoSitePlus
S1331 Phosphorylation PhosphoSitePlus
T1336 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1345 Phosphorylation HPRD 20068231
T1385 Phosphorylation PhosphoSitePlus
S1430 Phosphorylation PhosphoSitePlus
K1470 Ubiquitination PhosphoSitePlus
S1478 Phosphorylation PhosphoSitePlus
S1513 Phosphorylation PhosphoSitePlus
S1521 Phosphorylation PhosphoSitePlus
S1663 Phosphorylation PhosphoSitePlus
T1669 Phosphorylation PhosphoSitePlus
S1717 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1720 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1725 Phosphorylation PhosphoSitePlus
S1811 Phosphorylation PhosphoSitePlus
S1961 Phosphorylation PhosphoSitePlus
T1991 Phosphorylation PhosphoSitePlus
S2005 Phosphorylation PhosphoSitePlus
S2011 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S43 L43 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S43 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S232 A232 Biomuta DOID:263 / kidney cancer [ cosmic ]
S379 W379 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S383 I383 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S387 F387 Biomuta DOID:4159 / skin cancer [ cosmic ]
S390 G390 Biomuta DOID:263 / kidney cancer [ cosmic ]
T396 M396 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S410 P410 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R429 W429 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R433 Q433 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S461 F461 Biomuta DOID:4159 / skin cancer [ cosmic ]
S476 I476 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T530 M530 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ]
S546 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S613 N613 Biomuta DOID:4159 / skin cancer [ cosmic ]
S764 I764 Biomuta DOID:363 / uterine cancer [ icgc ]
S790 G790 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S914 F914 Biomuta [ cosmic ]
S948 F948 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S961 T961 Biomuta DOID:1324 / lung cancer [ cosmic ]
S961 C961 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1007 A1007 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T1336 M1336 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1478 R1478 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1725 I1725 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1725 C1725 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S1811 A1811 Biomuta DOID:5041 / esophageal cancer [ cosmic ]