iPTMnet Report for Q96PC5 (MIA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96PC5 / MIA2_HUMAN
Protein Name Melanoma inhibitory activity protein 2 precursor
Gene Name Name: MIA2
Synonyms:CTAGE5;
Organism Homo sapiens (Human)

PRO ID PR:Q96PC5
DAG View
PRO Name melanoma inhibitory activity protein 2 (human)
Definition A melanoma inhibitory activity protein 2 that is encoded in the genome of human.
Short Label hMIA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96PC5 (MIA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S249 Phosphorylation PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
S253 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
T325 O-Glycosylation GlyGen 25367160
T435 Phosphorylation PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
K741 Ubiquitination PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
K758 Ubiquitination PhosphoSitePlus
K779 Ubiquitination PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus
K929 Ubiquitination PhosphoSitePlus
S933 O-Glycosylation GlyGen 25367160
K935 Ubiquitination PhosphoSitePlus
K1044 Ubiquitination PhosphoSitePlus
K1066 Ubiquitination PhosphoSitePlus
K1067 Ubiquitination PhosphoSitePlus
K1108 Ubiquitination PhosphoSitePlus
S1125 Phosphorylation PhosphoSitePlus
Y1127 Phosphorylation PhosphoSitePlus
S1130 Phosphorylation PhosphoSitePlus
S1144 Phosphorylation PhosphoSitePlus
S1156 Phosphorylation PhosphoSitePlus
R1165 Methylation PhosphoSitePlus
S1167 Phosphorylation PhosphoSitePlus
R1168 Methylation PhosphoSitePlus
R1182 Methylation PhosphoSitePlus
T1191 Phosphorylation PhosphoSitePlus
S1202 Phosphorylation PhosphoSitePlus
S1204 Phosphorylation PhosphoSitePlus
S1243 Phosphorylation PhosphoSitePlus
S1255 Phosphorylation PhosphoSitePlus
S1262 Phosphorylation PhosphoSitePlus
R1322 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
R764 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S125 Phosphorylation HPRD 18669648, 20068231
S127 Phosphorylation HPRD 18669648
S505 Phosphorylation HPRD 19651622, 18669648, 20068231
Y507 Phosphorylation HPRD 19651622, 18669648, 20068231
S510 Phosphorylation HPRD 19651622, 18669648, 20068231
S524 Phosphorylation HPRD 19651622, 18669648, 20058876, ...17081983, 20068231
T527 Phosphorylation HPRD 18669648
S536 Phosphorylation HPRD 19651622, 20068231
S547 Phosphorylation HPRD 19651622
T571 Phosphorylation HPRD 17081983
S578 Phosphorylation HPRD 19651622, 17081983
T580 Phosphorylation HPRD 19651622, 17081983
S582 Phosphorylation HPRD 19651622, 20166139, 17081983
S584 Phosphorylation HPRD 19651622, 20166139, 17081983
S619 Phosphorylation HPRD 20068231
S623 Phosphorylation HPRD 18669648, 17081983, 20068231
S635 Phosphorylation HPRD 19651622, 18767875, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S65 Phosphorylation PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
T122 Phosphorylation PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
S137 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S139 Phosphorylation HPRD   PhosphoSitePlus 18669648
K150 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
T401 Phosphorylation PhosphoSitePlus
Y406 Phosphorylation PhosphoSitePlus
T430 Phosphorylation PhosphoSitePlus
Y431 Phosphorylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
Y503 Phosphorylation PhosphoSitePlus
T510 Phosphorylation PhosphoSitePlus
S517 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20068231
Y519 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20068231
S522 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20068231
T531 Phosphorylation PhosphoSitePlus
S536 Phosphorylation HPRD   PhosphoSitePlus 17081983, 20058876, 19651622, ...18669648, 20068231
T539 Phosphorylation HPRD   PhosphoSitePlus 18669648
R546 Methylation PhosphoSitePlus
S548 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
R557 Methylation PhosphoSitePlus
S559 Phosphorylation HPRD   PhosphoSitePlus 19651622
R560 Methylation PhosphoSitePlus
T571 Phosphorylation PhosphoSitePlus
R574 Methylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
T583 Phosphorylation HPRD   PhosphoSitePlus 17081983
S590 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983
T592 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983
S594 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20166139, 17081983
S596 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20166139, 17081983
S631 Phosphorylation HPRD   PhosphoSitePlus 20068231
S635 Phosphorylation HPRD   PhosphoSitePlus 18669648, 17081983, 20068231
S642 Phosphorylation PhosphoSitePlus
S647 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231, 18767875
S654 Phosphorylation PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus
S661 Phosphorylation PhosphoSitePlus
S662 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus
R709 Methylation PhosphoSitePlus
R714 Methylation PhosphoSitePlus
R715 Methylation PhosphoSitePlus
R751 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
R514 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S108 Phosphorylation HPRD 18669648, 20068231
S110 Phosphorylation HPRD 18669648
S488 Phosphorylation HPRD 19651622, 18669648, 20068231
Y490 Phosphorylation HPRD 19651622, 18669648, 20068231
S493 Phosphorylation HPRD 19651622, 18669648, 20068231
S507 Phosphorylation HPRD 19651622, 18669648, 20058876, ...17081983, 20068231
T510 Phosphorylation HPRD 18669648
S519 Phosphorylation HPRD 19651622, 20068231
S530 Phosphorylation HPRD 19651622
T554 Phosphorylation HPRD 17081983
S561 Phosphorylation HPRD 19651622, 17081983
T563 Phosphorylation HPRD 19651622, 17081983
S565 Phosphorylation HPRD 19651622, 20166139, 17081983
S567 Phosphorylation HPRD 19651622, 20166139, 17081983
S602 Phosphorylation HPRD 20068231
S606 Phosphorylation HPRD 18669648, 17081983, 20068231
S618 Phosphorylation HPRD 19651622, 18767875, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S65 L65 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S65 W65 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
K95 N95 Biomuta DOID:4159 / skin cancer [ cosmic ]
S110 C110 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K113 E113 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
T122 K122 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S127 C127 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S139 C139 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S253 N253 Biomuta DOID:4159 / skin cancer [ cosmic ]
S253 R253 Biomuta DOID:4159 / skin cancer [ cosmic ]
S292 F292 Biomuta DOID:4159 / skin cancer [ cosmic ]
S488 F488 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S505 F505 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T510 K510 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R514 I514 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S517 F517 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S530 L530 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S547 L547 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R557 K557 Biomuta DOID:1324 / lung cancer [ cosmic ]
S559 L559 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R560 Q560 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S565 F565 Biomuta DOID:4159 / skin cancer [ cosmic ]
S582 F582 Biomuta DOID:4159 / skin cancer [ cosmic ]
S593 F593 Biomuta DOID:4159 / skin cancer [ cosmic ]
S594 F594 Biomuta DOID:4159 / skin cancer [ cosmic ]
S602 F602 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S602 Y602 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S619 F619 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S619 Y619 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S631 F631 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S631 Y631 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S661 C661 Biomuta DOID:1612 / breast cancer [ cosmic ]
K703 N703 Biomuta DOID:4159 / skin cancer [ cosmic ]
R709 I709 Biomuta DOID:1324 / lung cancer [ cosmic ]
R715 G715 Biomuta [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K721 E721 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S747 C747 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R751 I751 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1125 F1125 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1165 K1165 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1167 L1167 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1168 Q1168 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1202 F1202 Biomuta DOID:4159 / skin cancer [ cosmic ]