iPTMnet Report for Q96P20 (NLRP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96P20 / NLRP3_HUMAN
Protein Name NACHT, LRR and PYD domains-containing protein 3
Gene Name Name: NLRP3
Synonyms:C1orf7;
Organism Homo sapiens (Human)

PRO ID PR:Q96P20
DAG View
PRO Name NACHT, LRR and PYD domains-containing protein 3 (human)
Definition A NACHT, LRR and PYD domains-containing protein 3 that is encoded in the genome of human.
Short Label hNLRP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96P20 (NLRP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S5 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32929041, 32983094, 28465465, ...28716882
Y13 Phosphorylation PhosphoSitePlus   UniProt 28943315
Y136 Phosphorylation UniProt 34554188
Y140 Phosphorylation UniProt 34554188
Y143 Phosphorylation UniProt 34554188
S161 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus   UniProt 28943315
Y168 Phosphorylation UniProt 34554188
S198 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 28943315, 32778128, 35114687
S201 Phosphorylation UniProt 35114687
T233 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus   RLIMS-P 33375031
S334 Phosphorylation PhosphoSitePlus   UniProt 28943315
S387 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
T659 Phosphorylation PhosphoSitePlus
K689 Ubiquitination UniProt 26037928
S728 Phosphorylation PhosphoSitePlus   UniProt 28943315
S735 Phosphorylation PhosphoSitePlus   UniProt 34615873
S806 Phosphorylation PhosphoSitePlus   UniProt 34615873
Y861 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 27043286
K878 Ubiquitination PhosphoSitePlus   UniProt 34615873
K927 Ubiquitination PhosphoSitePlus   UniProt 34615873
K973 Ubiquitination PhosphoSitePlus   UniProt 34615873
S975 Phosphorylation PhosphoSitePlus   UniProt 28943315
S1035 Phosphorylation PhosphoSitePlus   UniProt 34615873


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048612 (hNLRP3/UbiqLys+) ub PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96P20 (NLRP3) S295 Q9ULZ3 (PYCARD) inhibited_association eFIP 33627128