iPTMnet Report for Q96P11 (NSUN5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96P11 / NSUN5_HUMAN
Protein Name 28S rRNA (cytosine-C(5))-methyltransferase
Gene Name Name: NSUN5
Synonyms:NSUN5A;
Organism Homo sapiens (Human)

PRO ID PR:Q96P11
DAG View
PRO Name 28S rRNA (cytosine-C(5))-methyltransferase (human)
Definition A 28S rRNA (cytosine-C(5))-methyltransferase that is encoded in the genome of human.
Short Label hNSUN5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96P11 (NSUN5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K22 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
Y37 Phosphorylation PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
R85 Methylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K103 Sumoylation PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K144 Methylation PhosphoSitePlus
K144 Sumoylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K155 Methylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K177 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
S327 Phosphorylation PhosphoSitePlus
R340 Methylation PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T195 Phosphorylation HPRD 20068231
T325 Phosphorylation HPRD 18669648, 20068231
S327 Phosphorylation HPRD 18767875, 18669648, 15302935, ...19664995, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T195 Phosphorylation HPRD 20068231
T325 Phosphorylation HPRD 18669648, 20068231
S327 Phosphorylation HPRD 18767875, 18669648, 15302935, ...19664995, 20068231
S432 Phosphorylation HPRD   PhosphoSitePlus 17525332
K435 Ubiquitination PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
T442 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20068231
S444 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 20068231
T462 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19664995
T466 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R85 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S167 N167 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K262 R262 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K262 N262 Biomuta DOID:263 / kidney cancer [ cosmic ]
R340 Q340 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K435 E435 Biomuta DOID:1324 / lung cancer [ cosmic ]