iPTMnet Report for Q96NY9 (MUS81)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96NY9 / MUS81_HUMAN
Protein Name Crossover junction endonuclease MUS81
Gene Name Name: MUS81
Organism Homo sapiens (Human)

PRO ID PR:Q96NY9
DAG View
PRO Name crossover junction endonuclease MUS81 (human)
Definition A crossover junction endonuclease MUS81 that is encoded in the genome of human.
Short Label hMUS81
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96NY9 (MUS81) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Sumoylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus   RLIMS-P 29850896, 31114910
S95 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S97 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus   UniProt 23186163
S115 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S408 Phosphorylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K524 Sumoylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96NY9 (MUS81) S87 Q8IY92 (SLX4) unknown eFIP 29850896
Phosphorylation Q96NY9 (MUS81) S87 Q96AY2 (EME1) inhibited_association eFIP 29850896


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S87 L87 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S95 L95 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S97 P97 Biomuta DOID:3277 / thymus cancer [ cosmic ]
S101 N101 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S178 G178 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K335 N335 Biomuta DOID:363 / uterine cancer [ icgc ]