iPTMnet Report for Q96N22 (ZNF681)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96N22 / ZN681_HUMAN
Protein Name Zinc finger protein 681
Gene Name Name: ZNF681
Organism Homo sapiens (Human)

PRO ID PR:Q96N22
DAG View
PRO Name zinc finger protein 681 (human)
Definition A zinc finger protein 681 that is encoded in the genome of human.
Short Label hZNF681
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96N22 (ZNF681) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T136 Phosphorylation PhosphoSitePlus
T137 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
Y282 Phosphorylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K339 Acetylation PhosphoSitePlus
K339 Sumoylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
T361 Phosphorylation PhosphoSitePlus
K364 Sumoylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
T389 Phosphorylation PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K395 Acetylation PhosphoSitePlus
K395 Sumoylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K451 Sumoylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
T473 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K479 Sumoylation PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
K507 Sumoylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
T529 Phosphorylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
T585 Phosphorylation PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
T613 Phosphorylation PhosphoSitePlus
Y618 Phosphorylation PhosphoSitePlus
S625 Phosphorylation PhosphoSitePlus
T630 Phosphorylation PhosphoSitePlus
S631 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K336 R336 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
T361 A361 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
K364 R364 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K392 N392 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K395 Q395 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K426 E426 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T473 N473 Biomuta DOID:1319 / brain cancer [ cosmic ]
K479 R479 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
K594 E594 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
Y618 C618 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S625 N625 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T630 A630 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S631 L631 Biomuta DOID:4159 / skin cancer [ cosmic ]