Protein Information

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UniProt AC / UniProt ID Q96MU7 / YTDC1_HUMAN
Protein Name YTH domain-containing protein 1
Gene Name Name: YTHDC1
Synonyms:KIAA1966;
Organism Homo sapiens (Human)

PRO ID PR:Q96MU7
DAG View
PRO Name YTH domain-containing protein 1 (human)
Definition A YTH domain-containing protein 1 that is encoded in the genome of human.
Short Label hYTHDC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96MU7 (YTHDC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K58 Acetylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
K72 Acetylation PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K96 Sumoylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
S118 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S119 Phosphorylation PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus   UniProt 23186163
S122 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S146 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 17081983, 15302935, ...24275569, 20068231
T148 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 17081983, 15302935, ...24275569, 20068231
S152 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
T266 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S275 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S277 Phosphorylation PhosphoSitePlus
T291 Phosphorylation PhosphoSitePlus
S308 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...16964243, 15302935, 18669648, 24275569, 20068231, 17081983
S315 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S317 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 17081983
S318 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S320 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 17081983
S322 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
Y323 Phosphorylation PhosphoSitePlus
S326 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
S334 Phosphorylation PhosphoSitePlus
T345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
K349 Acetylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
S419 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S424 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
S435 Phosphorylation PhosphoSitePlus   UniProt 20068231
K469 Sumoylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
S515 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S519 Phosphorylation PhosphoSitePlus
Y540 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y553 Phosphorylation PhosphoSitePlus
Y569 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus
Y656 Phosphorylation PhosphoSitePlus
T667 Phosphorylation PhosphoSitePlus
S672 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 18452278
S71 Phosphorylation HPRD 20068231
S75 Phosphorylation HPRD 20068231
S79 Phosphorylation HPRD 20068231
S118 Phosphorylation HPRD 18669648, 19007248, 20068231
S119 Phosphorylation HPRD 19413330
S120 Phosphorylation HPRD 20068231
S122 Phosphorylation HPRD 18669648, 20068231
S146 Phosphorylation HPRD 19651622, 17081983, 20068231
T148 Phosphorylation HPRD 19651622, 17081983, 20068231
S152 Phosphorylation HPRD 17081983
S273 Phosphorylation HPRD 18452278
S275 Phosphorylation HPRD 18452278
S277 Phosphorylation HPRD 18452278
S308 Phosphorylation HPRD 19413330, 18691976, 18212344, ...20058876, 18707149, 19664994, 19007248, 18452278, 17322306, 18669648, 19651622, 19664995, 18767875, 19415658, 20068231, 20068230
S315 Phosphorylation HPRD 18669648, 17081983, 20068231
S317 Phosphorylation HPRD 18669648, 17081983, 20068231
S318 Phosphorylation HPRD 18669648, 17081983, 20068231
S320 Phosphorylation HPRD 18669648, 17081983, 20068231
S322 Phosphorylation HPRD 17081983
Y323 Phosphorylation HPRD 17081983
S326 Phosphorylation HPRD 17081983
S334 Phosphorylation HPRD 20068231
S336 Phosphorylation HPRD 20068231
T345 Phosphorylation HPRD 20068231
S346 Phosphorylation HPRD 20068231
S416 Phosphorylation HPRD 20068231
S417 Phosphorylation HPRD 20068231
S419 Phosphorylation HPRD 18669648, 20068231
S424 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231, 18452278
S435 Phosphorylation HPRD 19651622, 17081983, 20068231
S515 Phosphorylation HPRD 17081983, 20068231
S519 Phosphorylation HPRD 20068231
S545 Phosphorylation HPRD 20068231, 17924679
S577 Phosphorylation HPRD 19007248
Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation HPRD 18452278
S71 Phosphorylation HPRD 20068231
S75 Phosphorylation HPRD 20068231
S79 Phosphorylation HPRD 20068231
S118 Phosphorylation HPRD 18669648, 19007248, 20068231
S119 Phosphorylation HPRD 19413330
S120 Phosphorylation HPRD 20068231
S122 Phosphorylation HPRD 18669648, 20068231
S146 Phosphorylation HPRD 19651622, 15302935, 20068231
T148 Phosphorylation HPRD 19651622, 15302935, 20068231
S152 Phosphorylation HPRD 17081983
S273 Phosphorylation HPRD 18452278
S275 Phosphorylation HPRD 15302935, 18452278
S277 Phosphorylation HPRD 18452278
S308 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18691976, 18212344, ...20058876, 18707149, 15302935, 19007248, 18452278, 19651622, 19664994, 18669648, 19664995, 18767875, 16565220, 19415658, 20068231, 20068230
S318 Phosphorylation PhosphoSitePlus
S320 Phosphorylation HPRD   PhosphoSitePlus 15302935
T327 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
S398 Phosphorylation HPRD 20068231
S399 Phosphorylation HPRD 20068231
S401 Phosphorylation HPRD 18669648, 20068231
S406 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231, 18452278
S417 Phosphorylation HPRD 19651622, 17081983, 20068231
S497 Phosphorylation HPRD 17081983, 20068231
S501 Phosphorylation HPRD 20068231
S527 Phosphorylation HPRD 20068231, 17924679
S559 Phosphorylation HPRD 19007248


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S49 N49 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K96 T96 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T148 M148 Biomuta DOID:0070003 / blastoma [ cosmic ]
S164 C164 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S164 N164 Biomuta DOID:363 / uterine cancer [ tcga ]
Y264 C264 Biomuta DOID:1115 / sarcoma [ tcga ]
S273 C273 Biomuta DOID:1324 / lung cancer [ cosmic ]
S308 Y308 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S334 P334 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S334 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S435 N435 Biomuta DOID:363 / uterine cancer [ tcga ]