iPTMnet Report for Q96MF7 (NSMCE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96MF7 / NSE2_HUMAN
Protein Name E3 SUMO-protein ligase NSE2
Gene Name Name: NSMCE2
Synonyms:C8orf36,MMS21;
Organism Homo sapiens (Human)

PRO ID PR:Q96MF7
DAG View
PRO Name E3 SUMO-protein ligase NSE2 (human)
Definition An E3 SUMO-protein ligase NSE2 that is encoded in the genome of human.
Short Label hNSMCE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96MF7 (NSMCE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 20068231
S5 Phosphorylation HPRD 20068231
S6 Phosphorylation HPRD 20068231
S7 Phosphorylation HPRD   PhosphoSitePlus 20068231
S11 Phosphorylation HPRD 20068231
T12 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
S22 Phosphorylation HPRD 20068231
S26 Phosphorylation HPRD 20068231
K80 Ubiquitination PhosphoSitePlus
K90 Sumoylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K101 Sumoylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K107 Sumoylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus   UniProt 23186163
K125 Acetylation PhosphoSitePlus
K125 Sumoylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K130 Sumoylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
Y209 Phosphorylation HPRD   PhosphoSitePlus 17924679
S216 Phosphorylation HPRD   PhosphoSitePlus 17924679
K222 Sumoylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S11 L11 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S11 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K107 N107 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K125 T125 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K130 I130 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]