Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96M96 / FGD4_HUMAN
Protein Name FYVE, RhoGEF and PH domain-containing protein 4
Gene Name Name: FGD4
Synonyms:FRABP,ZFYVE6;
Organism Homo sapiens (Human)

PRO ID PR:Q96M96
DAG View
PRO Name FYVE, RhoGEF and PH domain-containing protein 4 (human)
Definition A FYVE, RhoGEF and PH domain-containing protein 4 that is encoded in the genome of human.
Short Label hFGD4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96M96 (FGD4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K16 Ubiquitination PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
T52 Phosphorylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
T158 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
Y407 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
Y453 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
Y602 Phosphorylation PhosphoSitePlus
Y615 Phosphorylation PhosphoSitePlus
S702 Phosphorylation PhosphoSitePlus   UniProt 24275569
S716 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y355 Phosphorylation HPRD 20068231
S463 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 I37 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y407 N407 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S716 F716 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]