Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96L73 / NSD1_HUMAN
Protein Name Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific
Gene Name Name: NSD1
Synonyms:ARA267,KMT3B;
Organism Homo sapiens (Human)

PRO ID PR:Q96L73
DAG View
PRO Name histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (human)
Definition A histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific that is encoded in the genome of human.
Short Label hNSD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96L73 (NSD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S117 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
T233 Phosphorylation PhosphoSitePlus
S316 Phosphorylation phospho.ELM 18669648
T317 Phosphorylation PhosphoSitePlus
K320 Sumoylation PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S486 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
K501 Methylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
T563 Phosphorylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
K606 Acetylation PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus
K734 Ubiquitination PhosphoSitePlus
S752 Phosphorylation PhosphoSitePlus
S766 Phosphorylation UniProt 17487921
S780 Phosphorylation PhosphoSitePlus
S811 Phosphorylation PhosphoSitePlus
S822 Phosphorylation PhosphoSitePlus
K837 Sumoylation PhosphoSitePlus
K837 Ubiquitination PhosphoSitePlus
S849 Phosphorylation PhosphoSitePlus
S850 Phosphorylation PhosphoSitePlus
T854 Phosphorylation PhosphoSitePlus
K858 Ubiquitination PhosphoSitePlus
K865 Ubiquitination PhosphoSitePlus
K886 Ubiquitination PhosphoSitePlus
Y936 Phosphorylation PhosphoSitePlus
S938 Phosphorylation PhosphoSitePlus
S948 Phosphorylation PhosphoSitePlus
S958 Phosphorylation PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
S965 Phosphorylation PhosphoSitePlus
S1024 Phosphorylation PhosphoSitePlus
T1042 Phosphorylation PhosphoSitePlus
S1077 Phosphorylation PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus
T1208 Phosphorylation PhosphoSitePlus
S1210 Phosphorylation PhosphoSitePlus
S1243 Phosphorylation PhosphoSitePlus
T1257 Phosphorylation PhosphoSitePlus
S1269 Phosphorylation PhosphoSitePlus
K1299 Acetylation PhosphoSitePlus
K1300 Acetylation PhosphoSitePlus
S1334 Phosphorylation PhosphoSitePlus
T1338 Phosphorylation PhosphoSitePlus
K1339 Sumoylation PhosphoSitePlus
S1382 Phosphorylation PhosphoSitePlus
K1411 Sumoylation PhosphoSitePlus
T1446 Phosphorylation PhosphoSitePlus
S1454 Phosphorylation PhosphoSitePlus
K1480 Acetylation PhosphoSitePlus
S1498 Phosphorylation PhosphoSitePlus
T1507 Phosphorylation PhosphoSitePlus
S1510 Phosphorylation PhosphoSitePlus
K1542 Ubiquitination PhosphoSitePlus
T1694 Phosphorylation PhosphoSitePlus
Y1815 Phosphorylation PhosphoSitePlus
K1871 Ubiquitination PhosphoSitePlus
T1886 Phosphorylation PhosphoSitePlus
S1890 Phosphorylation PhosphoSitePlus
K1964 Ubiquitination PhosphoSitePlus
R1986 Methylation PhosphoSitePlus
Y1987 Phosphorylation PhosphoSitePlus
T1994 Phosphorylation PhosphoSitePlus
K2012 Ubiquitination PhosphoSitePlus
K2086 Acetylation PhosphoSitePlus
K2095 Acetylation PhosphoSitePlus
T2109 Phosphorylation PhosphoSitePlus
S2288 Phosphorylation PhosphoSitePlus
S2334 Phosphorylation PhosphoSitePlus
S2364 Phosphorylation PhosphoSitePlus
S2369 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2374 Phosphorylation PhosphoSitePlus
S2379 Phosphorylation PhosphoSitePlus
T2382 Phosphorylation PhosphoSitePlus
R2385 Methylation PhosphoSitePlus
T2462 Phosphorylation PhosphoSitePlus   UniProt 20068231
S2471 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T2476 Phosphorylation PhosphoSitePlus
S2489 Phosphorylation PhosphoSitePlus
S2490 Phosphorylation PhosphoSitePlus
K2506 Methylation PhosphoSitePlus
K2518 Methylation PhosphoSitePlus
K2531 Ubiquitination PhosphoSitePlus
K2545 Sumoylation PhosphoSitePlus
S2560 Phosphorylation PhosphoSitePlus
S2573 Phosphorylation PhosphoSitePlus
K2581 Methylation PhosphoSitePlus
K2616 Sumoylation PhosphoSitePlus
K2616 Ubiquitination PhosphoSitePlus
S2623 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S316 Phosphorylation HPRD 18669648
S483 Phosphorylation HPRD 19413330, 19651622, 20068231
S486 Phosphorylation HPRD 19413330, 19651622, 20068231
S780 Phosphorylation HPRD 20068231
S961 Phosphorylation HPRD 20068231
T962 Phosphorylation HPRD 20068231
S1024 Phosphorylation HPRD 20068231
S1027 Phosphorylation HPRD 20068231
T1338 Phosphorylation HPRD 20068231
S2369 Phosphorylation HPRD 19664995, 20068231
T2378 Phosphorylation HPRD 20068231
T2462 Phosphorylation HPRD 20068231
S2471 Phosphorylation HPRD 19651622, 18669648, 19664995
S2573 Phosphorylation HPRD 19664995, 20068231
S2599 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation HPRD 18669648
S214 Phosphorylation HPRD 19413330, 19651622, 20068231
S217 Phosphorylation HPRD 19413330, 19651622, 20068231
S511 Phosphorylation HPRD 20068231
S692 Phosphorylation HPRD 20068231
T693 Phosphorylation HPRD 20068231
S755 Phosphorylation HPRD 20068231
S758 Phosphorylation HPRD 20068231
T1069 Phosphorylation HPRD 20068231
S2100 Phosphorylation HPRD 19664995, 20068231
T2109 Phosphorylation HPRD 20068231
T2193 Phosphorylation HPRD 20068231
S2202 Phosphorylation HPRD 19651622, 18669648, 19664995
S2304 Phosphorylation HPRD 19664995, 20068231
S2330 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T214 I214 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T233 I233 Biomuta DOID:3070 / malignant glioma [ icgc ]
K320 R320 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
S343 Y343 Biomuta DOID:363 / uterine cancer [ tcga ]
S451 I451 Biomuta DOID:10534 / stomach cancer [ tcga ]
S486 C486 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T563 P563 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S589 C589 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K601 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
S726 P726 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K734 R734 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S766 L766 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S780 L780 Biomuta DOID:1909 / melanoma [ tcga ]
S822 F822 Biomuta DOID:0070003 / blastoma [ cosmic ]
S958 L958 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S958 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S1334 Y1334 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
T1338 A1338 Biomuta DOID:3070 / malignant glioma [ cosmic ]
K1964 N1964 Biomuta DOID:1612 / breast cancer [ cosmic ]
R1986 H1986 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R1986 C1986 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
Y1987 C1987 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K2095 R2095 Biomuta DOID:263 / kidney cancer [ tcga ]
T2109 A2109 Biomuta DOID:363 / uterine cancer [ tcga ]
K2545 N2545 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S2599 A2599 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S2623 R2623 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]