iPTMnet Report for Q96KS0 (EGLN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96KS0 / EGLN2_HUMAN
Protein Name Prolyl hydroxylase EGLN2
Gene Name Name: EGLN2
Synonyms:EIT6;
Organism Homo sapiens (Human)

PRO ID PR:Q96KS0
DAG View
PRO Name prolyl hydroxylase EGLN2 (human)
Definition A prolyl hydroxylase EGLN2 that is encoded in the genome of human.
Short Label hEGLN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96KS0 (EGLN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C42 Methylation IEDB 31844290
T69 Phosphorylation PhosphoSitePlus
S74 Phosphorylation RLIMS-P 27263528
S130 Phosphorylation P11802 (CDK4) , Q00534 (CDK6) , P24941 (CDK2) PhosphoSitePlus   RLIMS-P   UniProt 26644182, 23186163
S132 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 18710826
S151 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
S162 Phosphorylation RLIMS-P 27263528
S226 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 18710826
S234 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 18710826
Y374 Phosphorylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C42 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S74 R74 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T405 M405 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]