iPTMnet Report for Q96KP1 (EXOC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96KP1 / EXOC2_HUMAN
Protein Name Exocyst complex component 2
Gene Name Name: EXOC2
Synonyms:SEC5,SEC5L1;
Organism Homo sapiens (Human)

PRO ID PR:Q96KP1
DAG View
PRO Name exocyst complex component 2 (human)
Definition An exocyst complex component 2 that is encoded in the genome of human.
Short Label hEXOC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96KP1 (EXOC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C62 Methylation IEDB 31844290
K71 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
R83 Methylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
Y204 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S250 Phosphorylation PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
T255 Phosphorylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
Y299 Phosphorylation PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K342 Acetylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
Y392 Phosphorylation PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
S426 Phosphorylation HPRD   PhosphoSitePlus 20068231
K428 Ubiquitination PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus   UniProt 23186163
S432 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 15302935
S435 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 17081983, 18452278
T440 Phosphorylation PhosphoSitePlus   UniProt 23186163
K454 Acetylation PhosphoSitePlus   UniProt 19608861
K454 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K532 Ubiquitination PhosphoSitePlus
Y534 Phosphorylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
C719 Methylation IEDB 31844290
K743 Ubiquitination PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
C842 Methylation IEDB 31844290
K848 Ubiquitination PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
K878 Ubiquitination PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus   UniProt 23186163
K894 Ubiquitination PhosphoSitePlus
K902 Ubiquitination PhosphoSitePlus
C913 Methylation IEDB 31844290
T924 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R83 G83 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y113 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K281 Q281 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y392 F392 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S426 Y426 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S431 I431 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S431 N431 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S432 I432 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K454 R454 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K515 N515 Biomuta DOID:4159 / skin cancer [ cosmic ]
C719 Y719 Biomuta DOID:263 / kidney cancer [ cosmic ]
C719 S719 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T924 A924 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]