Protein Information

Cytoscape View

UniProt AC / UniProt ID Q96KK5 / H2A1H_HUMAN
Protein Name Histone H2A type 1-H
Gene Name Name: H2AC12
Organism Homo sapiens (Human)

DAG View
PRO Name histone H2A type 1-H (human)
Definition A histone H2A type 1-H that is encoded in the genome of human.
Short Label hH2AC12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q96KK5 (H2AC12) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
S2 Acetylation UniProt 15823041
S2 Phosphorylation PRO   PhosphoSitePlus   UniProt 15010469
K6 Acetylation PRO   PhosphoSitePlus 17709392
K6 Methylation PhosphoSitePlus
K10 Acetylation PRO   PhosphoSitePlus 18552846, 12937907
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination UniProt 22713238, 22980979
K16 Ubiquitination UniProt 22713238, 22980979
S20 Phosphorylation PhosphoSitePlus
R21 Methylation PhosphoSitePlus
R30 Methylation PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
Y40 Phosphorylation PhosphoSitePlus
R82 Methylation PhosphoSitePlus
R89 Methylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Methylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
Q105 Methylation UniProt 24352239
K119 Acetylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Sumoylation PhosphoSitePlus
K120 Ubiquitination PRO   PhosphoSitePlus   UniProt 18400894, 25470042, 16359901, ...15386022, 16702407
T121 Phosphorylation PRO   PhosphoSitePlus   UniProt 19965387, 24140421, 15078818
S123 Phosphorylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044949 (hHIST1H2AH/InitMet-/Ac:1) acK6 PRO 17709392
PR:000044950 (hHIST1H2AH/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000044951 (hHIST1H2AH/InitMet-/Phos:1) pS2 PRO 15010469
PR:000044953 (hHIST1H2AH/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000044958 (hHIST1H2AH/InitMet-/Phos:2) pT121 PRO 19965387
PR:000047742 (hHIST1H2AH/InitMet-/N6AcLys+) ac PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 A2 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S2 C2 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R21 G21 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
R30 Q30 Biomuta DOID:11934 / head and neck cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
T102 S102 Biomuta DOID:1324 / lung cancer [ cosmic ]