Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96KB5 / TOPK_HUMAN
Protein Name Lymphokine-activated killer T-cell-originated protein kinase
Gene Name Name: PBK
Synonyms:TOPK;
Organism Homo sapiens (Human)

PRO ID PR:Q96KB5
DAG View
PRO Name lymphokine-activated killer T-cell-originated protein kinase (human)
Definition A lymphokine-activated killer T-cell-originated protein kinase that is encoded in the genome of human.
Short Label hPBK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96KB5 (PBK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22223895, 20068231
S5 Phosphorylation PhosphoSitePlus
K8 Sumoylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
T9 Phosphorylation P06493 (CDK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 25575812, 28780319, ...28412249, 15541388, 16316408, 20068231
S11 Phosphorylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K12 Sumoylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
K16 Acetylation PhosphoSitePlus
K17 Acetylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S23 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T24 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 28780319
T26 Phosphorylation PhosphoSitePlus
S32 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 20068231, 28780319
Y47 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S57 Phosphorylation PhosphoSitePlus
S59 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 28780319, ...20068231
K64 Acetylation PhosphoSitePlus
K64 Sumoylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K65 Sumoylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
Y74 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P+ 27016416
S76 Phosphorylation PhosphoSitePlus
Y78 Phosphorylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
S91 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
K155 Sumoylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K162 Sumoylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K169 Sumoylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
K176 Sumoylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
T198 Phosphorylation RLIMS-P 16316408
K213 Ubiquitination PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
Y272 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P+ 27016416
S310 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T9 Phosphorylation P14635 (CCNB1) , P06493 (CDK1) HPRD 19413330, 15541388, 20068231
S19 Phosphorylation HPRD 17322306
S23 Phosphorylation HPRD 18669648
T24 Phosphorylation HPRD 19413330, 18669648, 20068231
T26 Phosphorylation HPRD 20068231
S32 Phosphorylation HPRD 17322306, 18669648, 20068231
S57 Phosphorylation HPRD 17322306
S59 Phosphorylation HPRD 17322306, 18669648, 20068231, ...17924679
S264 Phosphorylation HPRD 20068231
S310 Phosphorylation HPRD 20068231


Q96KB5 (PBK) as PTM Enzyme



Substrate Site Score Source PMID
P05412 (JUN) S63 PhosphoSitePlus 26745678
P05412 (JUN) S73 PhosphoSitePlus 26745678
P25963 (NFKBIA) S32 RLIMS-P+ 23250755
P31749 (AKT1) S473 RLIMS-P+ 21996732
P68431 (H3C12) S11 Signor 16982762
P81274 (GPSM2) T457 PhosphoSitePlus   Signor 20589935
Q06830 (PRDX1) S32 PhosphoSitePlus   Signor 20647304