iPTMnet Report for Q96JJ7 (TMX3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96JJ7 / TMX3_HUMAN
Protein Name Protein disulfide-isomerase TMX3 precursor
Gene Name Name: TMX3
Synonyms:KIAA1830,TXNDC10;
Organism Homo sapiens (Human)

PRO ID PR:Q96JJ7
DAG View
PRO Name protein disulfide-isomerase TMX3 (human)
Definition A protein disulfide-isomerase TXNDC10 that is encoded in the genome of human.
Short Label hTMX3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96JJ7 (TMX3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K58 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
Y111 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
N258 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 24190977
K267 Ubiquitination PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K119 Q119 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K414 E414 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S415 R415 Biomuta DOID:4159 / skin cancer [ cosmic ]
K446 N446 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ]