Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96JI7 / SPTCS_HUMAN
Protein Name Spatacsin
Gene Name Name: SPG11
Synonyms:KIAA1840;
Organism Homo sapiens (Human)

PRO ID PR:Q96JI7
DAG View
PRO Name spatacsin (human)
Definition A spatacsin that is encoded in the genome of human.
Short Label hSPG11
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96JI7 (SPG11) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S148 Phosphorylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
T644 Phosphorylation PhosphoSitePlus
K660 Ubiquitination PhosphoSitePlus
Y668 Phosphorylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
K739 Ubiquitination PhosphoSitePlus
K746 Ubiquitination PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
K819 Ubiquitination PhosphoSitePlus
K825 Methylation PhosphoSitePlus
K827 Ubiquitination PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
K839 Ubiquitination PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
K876 Ubiquitination PhosphoSitePlus
K942 Ubiquitination PhosphoSitePlus
T974 Phosphorylation PhosphoSitePlus
Y980 Phosphorylation PhosphoSitePlus
K981 Ubiquitination PhosphoSitePlus
K1024 Ubiquitination PhosphoSitePlus
K1110 Ubiquitination PhosphoSitePlus
K1117 Ubiquitination PhosphoSitePlus
Y1290 Phosphorylation PhosphoSitePlus
S1291 Phosphorylation PhosphoSitePlus
S1296 Phosphorylation PhosphoSitePlus
K1300 Ubiquitination PhosphoSitePlus
K1303 Ubiquitination PhosphoSitePlus
K1417 Ubiquitination PhosphoSitePlus
K1426 Ubiquitination PhosphoSitePlus
K1571 Ubiquitination PhosphoSitePlus
K1577 Ubiquitination PhosphoSitePlus
S1578 Phosphorylation PhosphoSitePlus
K1640 Ubiquitination PhosphoSitePlus
K1706 Ubiquitination PhosphoSitePlus
T1709 Phosphorylation PhosphoSitePlus
T1714 Phosphorylation PhosphoSitePlus
K1716 Ubiquitination PhosphoSitePlus
K1724 Ubiquitination PhosphoSitePlus
K1739 Ubiquitination PhosphoSitePlus
K1746 Ubiquitination PhosphoSitePlus
K1793 Sumoylation PhosphoSitePlus
S1827 Phosphorylation PhosphoSitePlus
T1828 Phosphorylation PhosphoSitePlus
K1853 Ubiquitination PhosphoSitePlus
K1863 Ubiquitination PhosphoSitePlus
S1955 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332, 18669648
T1956 Phosphorylation PhosphoSitePlus
S1957 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1958 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332, 18669648
S1961 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332, 18669648
K1963 Ubiquitination PhosphoSitePlus
T1966 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1983 Ubiquitination PhosphoSitePlus
K1988 Ubiquitination PhosphoSitePlus
K2022 Ubiquitination PhosphoSitePlus
K2045 Ubiquitination PhosphoSitePlus
K2071 Ubiquitination PhosphoSitePlus
K2099 Ubiquitination PhosphoSitePlus
Y2169 Phosphorylation PhosphoSitePlus
T2173 Phosphorylation PhosphoSitePlus
Y2174 Phosphorylation PhosphoSitePlus
K2182 Methylation PhosphoSitePlus
K2192 Ubiquitination PhosphoSitePlus
K2208 Ubiquitination PhosphoSitePlus
S2226 Phosphorylation PhosphoSitePlus
K2244 Ubiquitination PhosphoSitePlus
K2256 Ubiquitination PhosphoSitePlus
K2281 Ubiquitination PhosphoSitePlus
K2368 Ubiquitination PhosphoSitePlus
K2374 Ubiquitination PhosphoSitePlus
K2383 Ubiquitination PhosphoSitePlus
Y2404 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1955 Phosphorylation HPRD 19651622, 17525332, 18669648
S1957 Phosphorylation HPRD 18669648
S1958 Phosphorylation HPRD 17525332, 18669648
S1961 Phosphorylation HPRD 17525332, 18669648
T1966 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P20963 (CD247) Y72 Q96JI7 (SPG11) unknown eFIP 24502978


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K311 N311 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
S331 F331 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K350 N350 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K660 R660 Biomuta DOID:263 / kidney cancer [ tcga ]
Y668 * Biomuta DOID:2531 / hematologic cancer [ tcga ]
K819 M819 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K825 E825 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y980 N980 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S1291 T1291 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S1291 N1291 Biomuta DOID:363 / uterine cancer [ tcga ]
K1739 * Biomuta DOID:9256 / colorectal cancer [ tcga ]
K1739 N1739 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K1793 Q1793 Biomuta DOID:263 / kidney cancer [ tcga ]
T1956 N1956 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1958 N1958 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
K2045 T2045 Biomuta DOID:263 / kidney cancer [ cosmic ]
K2045 * Biomuta DOID:10534 / stomach cancer [ tcga ]
K2182 N2182 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:3963 / thyroid carcinoma [ icgc ]
K2208 E2208 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2226 C2226 Biomuta DOID:1324 / lung cancer [ tcga ]
Y2404 N2404 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]