iPTMnet Report for Q96JG6 (VPS50)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96JG6 / VPS50_HUMAN
Protein Name Syndetin
Gene Name Name: VPS50
Synonyms:CCDC132,KIAA1861;
Organism Homo sapiens (Human)

PRO ID PR:Q96JG6
DAG View
PRO Name syndetin (human)
Definition A syndetin that is encoded in the genome of human.
Short Label hVPS50
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96JG6 (VPS50) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K5 Acetylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 20068231
S19 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
Y260 Phosphorylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
T397 Phosphorylation PhosphoSitePlus
Y398 Phosphorylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
S492 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S496 Phosphorylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S500 Phosphorylation PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
Y557 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 19690332, 20068231
S561 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 19690332
Y571 Phosphorylation PhosphoSitePlus
K582 Ubiquitination PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
Y597 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
T608 Phosphorylation PhosphoSitePlus
Y621 Phosphorylation PhosphoSitePlus
S670 Phosphorylation PhosphoSitePlus
T674 Phosphorylation PhosphoSitePlus
T675 Phosphorylation PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
S810 Phosphorylation PhosphoSitePlus
Y815 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
C851 Methylation IEDB 31844290
T892 Phosphorylation PhosphoSitePlus
K963 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD 19651622, 18691976, 20068231
S492 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
S494 Phosphorylation HPRD 19651622, 18691976, 18669648, ...15302935, 20068231
S496 Phosphorylation HPRD 18691976
S498 Phosphorylation HPRD 19651622, 18669648, 15302935, ...20068231
S500 Phosphorylation HPRD 19651622, 18669648
S505 Phosphorylation HPRD 18669648
S546 Phosphorylation HPRD 19413330, 18691976, 18452278
Y557 Phosphorylation HPRD 19651622, 18691976, 18669648
S559 Phosphorylation HPRD 19413330, 18691976, 18452278, ...19651622, 18669648, 20166139, 20068231
S561 Phosphorylation HPRD 19413330, 18691976, 20058876, ...19651622, 18669648, 20166139
Y621 Phosphorylation HPRD 19664994
Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD 19651622, 18691976, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K255 M255 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K306 * Biomuta DOID:1319 / brain cancer [ cosmic ]
K306 M306 Biomuta DOID:1319 / brain cancer [ cosmic ]
K443 Q443 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S492 F492 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1324 / lung cancer [ cosmic ]
S494 F494 Biomuta DOID:4159 / skin cancer [ cosmic ]
S546 Y546 Biomuta DOID:3571 / liver cancer [ cosmic ]
S561 R561 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S585 Y585 Biomuta DOID:363 / uterine cancer [ icgc ]
S595 * Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
Y621 H621 Biomuta DOID:1319 / brain cancer [ cosmic ]
K963 E963 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]