iPTMnet Report for Q96JA1 (LRIG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96JA1 / LRIG1_HUMAN
Protein Name Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor
Gene Name Name: LRIG1
Synonyms:LIG1;
Organism Homo sapiens (Human)

PRO ID PR:Q96JA1
DAG View
PRO Name leucine-rich repeats and immunoglobulin-like domains protein 1 (human)
Definition A leucine-rich repeats and immunoglobulin-like domains protein 1 that is encoded in the genome of human.
Short Label hLRIG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96JA1 (LRIG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N74 N-Glycosylation GlyGen   UniProt 23090970, 25765764, 24190977
N150 N-Glycosylation GlyGen   UniProt 25765764
S187 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
N246 N-Glycosylation GlyGen   UniProt 25765764
S259 Phosphorylation PhosphoSitePlus
N292 N-Glycosylation GlyGen   UniProt 25765764
N317 N-Glycosylation GlyGen 24190977
N318 N-Glycosylation GlyGen   UniProt 25765764, 24190977
S331 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
T594 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
K603 Ubiquitination PhosphoSitePlus
T623 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K634 Ubiquitination PhosphoSitePlus
N684 N-Glycosylation GlyGen   UniProt 25765764
K715 Ubiquitination PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
Y941 Phosphorylation PhosphoSitePlus
Y996 Phosphorylation PhosphoSitePlus
Y1029 Phosphorylation PhosphoSitePlus
S1046 Phosphorylation PhosphoSitePlus
Y1054 Phosphorylation PhosphoSitePlus
S1069 Phosphorylation PhosphoSitePlus
S1093 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S187 P187 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N246 H246 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
N292 T292 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N317 D317 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
N318 S318 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K634 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K634 N634 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y996 H996 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1029 H1029 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1054 H1054 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]