Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96J92 / WNK4_HUMAN
Protein Name Serine/threonine-protein kinase WNK4
Gene Name Name: WNK4
Synonyms:PRKWNK4;
Organism Homo sapiens (Human)

PRO ID PR:Q96J92
DAG View
PRO Name serine/threonine-protein kinase WNK4 (human)
Definition A serine/threonine-protein kinase WNK4 that is encoded in the genome of human.
Short Label hWNK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96J92 (WNK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus   UniProt 23186163
R124 Methylation PhosphoSitePlus
K157 Ubiquitination UniProt 23576762
K175 Ubiquitination UniProt 23576762
S184 Phosphorylation PhosphoSitePlus
K186 Ubiquitination UniProt 23576762
S219 Phosphorylation PhosphoSitePlus
K226 Methylation PhosphoSitePlus
K226 Ubiquitination UniProt 23576762
S239 Phosphorylation PhosphoSitePlus
K241 Ubiquitination UniProt 23576762
S259 Phosphorylation PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
T326 Phosphorylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus   UniProt 23576762
S331 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus   RLIMS-P 29846116
K387 Ubiquitination UniProt 23576762
K393 Ubiquitination UniProt 23576762
K450 Ubiquitination UniProt 23576762
K454 Ubiquitination UniProt 23576762
S575 Phosphorylation P49137 (MAPKAPK2) PhosphoSitePlus   RLIMS-P 26732173
T679 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
K1010 Ubiquitination UniProt 23576762
Y1113 Phosphorylation P12931 (SRC) PhosphoSitePlus 25805816
Y1115 Phosphorylation P12931 (SRC) PhosphoSitePlus 25805816
K1144 Ubiquitination UniProt 23576762
T1151 Phosphorylation PhosphoSitePlus
T1154 Phosphorylation PhosphoSitePlus
K1157 Ubiquitination UniProt 23576762
K1158 Ubiquitination UniProt 23576762
Y1164 Phosphorylation P12931 (SRC) PhosphoSitePlus 25805816
S1190 Phosphorylation O00141 (SGK1) PhosphoSitePlus 19706464, 23054253
S1201 Phosphorylation O00141 (SGK1) PhosphoSitePlus 23054253
S1217 Phosphorylation O00141 (SGK1) PhosphoSitePlus 23054253
T1223 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1217 Phosphorylation HPRD 19651622


Q96J92 (WNK4) as PTM Enzyme



Substrate Site Score Source PMID
O95471 (CLDN7) S206 PhosphoSitePlus 17651736
Q9UEW8 (STK39) T231 neXtProt 19633012, 20463172, 16083423
Q9UEW8 (STK39) S371 neXtProt 19633012, 20463172, 16083423


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9UH77 (KLHL3) S433 Q96J92 (WNK4) inhibited_association eFIP 30718414
Phosphorylation Q9UH77 (KLHL3) S433 Q96J92 (WNK4) inhibited_association eFIP 27727489


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K157 N157 Biomuta DOID:3070 / malignant glioma [ tcga ]
T261 M261 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S680 C680 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y1113 H1113 Biomuta DOID:0070003 / blastoma [ cosmic ]
T1223 S1223 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]