iPTMnet Report for Q96J92 (WNK4)
Protein Information
| UniProt AC / UniProt ID | Q96J92 / WNK4_HUMAN |
| Protein Name | Serine/threonine-protein kinase WNK4 |
| Gene Name | Name: WNK4 Synonyms:PRKWNK4; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q96J92 |
| PRO Name | serine/threonine-protein kinase WNK4 (human) |
| Definition | A serine/threonine-protein kinase WNK4 that is encoded in the genome of human. |
| Short Label | hWNK4 |
| Category | organism-gene |
DAG ViewQ96J92 (WNK4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S47 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S64 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S97 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| R124 | Methylation | score1 | PhosphoSitePlus | |||
| K157 | Ubiquitination | score2 | UniProt | 23576762 | ||
| K175 | Ubiquitination | score2 | UniProt | 23576762 | ||
| S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K186 | Ubiquitination | score2 | UniProt | 23576762 | ||
| S219 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K226 | Methylation | score1 | PhosphoSitePlus | |||
| K226 | Ubiquitination | score2 | UniProt | 23576762 | ||
| S239 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K241 | Ubiquitination | score2 | UniProt | 23576762 | ||
| S259 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T261 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T326 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K328 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 23576762 | ||
| S331 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 32387766, 29493099, 27869121, ... | ||
| S335 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 29846116 | ||
| K387 | Ubiquitination | score2 | UniProt | 23576762 | ||
| K393 | Ubiquitination | score2 | UniProt | 23576762 | ||
| K450 | Ubiquitination | score2 | UniProt | 23576762 | ||
| K454 | Ubiquitination | score2 | UniProt | 23576762 | ||
| S575 | Phosphorylation | P49137 (MAPKAPK2) | score3 | PhosphoSitePlus RLIMS-P UniProt | 26732173 | |
| T679 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S680 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1010 | Ubiquitination | score2 | UniProt | 23576762 | ||
| S1022 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1023 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y1113 | Phosphorylation | P12931 (SRC) | score2 | PhosphoSitePlus | 25805816 | |
| Y1115 | Phosphorylation | P12931 (SRC) | score2 | PhosphoSitePlus | 25805816 | |
| K1144 | Ubiquitination | score2 | UniProt | 23576762 | ||
| T1151 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1154 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1157 | Ubiquitination | score2 | UniProt | 23576762 | ||
| K1158 | Ubiquitination | score2 | UniProt | 23576762 | ||
| Y1164 | Phosphorylation | P12931 (SRC) | score2 | PhosphoSitePlus | 25805816 | |
| S1190 | Phosphorylation | O00141 (SGK1) | score3 | PhosphoSitePlus | 19706464, 23054253 | |
| S1201 | Phosphorylation | O00141 (SGK1) | score2 | PhosphoSitePlus | 23054253 | |
| S1217 | Phosphorylation | O00141 (SGK1) | score2 | PhosphoSitePlus | 23054253 | |
| T1223 | Phosphorylation | score1 | PhosphoSitePlus |
Q96J92 (WNK4) as PTM Enzyme
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9UH77 (KLHL3) | S433 | Q96J92 (WNK4) | inhibited_association | eFIP | 27727489 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S64 | L64 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| K157 | N157 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
| S219 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K226 | N226 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S239 | L239 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S259 | L259 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S259 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T261 | M261 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] | |
| K387 | N387 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S680 | C680 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| Y1113 | H1113 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| K1158 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T1223 | S1223 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
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