iPTMnet Report for Q96J02 (ITCH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96J02 / ITCH_HUMAN
Protein Name E3 ubiquitin-protein ligase Itchy homolog
Gene Name Name: ITCH
Organism Homo sapiens (Human)

PRO ID PR:Q96J02
DAG View
PRO Name E3 ubiquitin-protein ligase Itchy homolog (human)
Definition An E3 ubiquitin-protein ligase Itchy that is encoded in the genome of human.
Short Label hITCH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96J02 (ITCH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K53 Methylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
T218 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S240 Phosphorylation neXtProt   PhosphoSitePlus   Signor 16446428
S240 Phosphorylation P45983 (MAPK8) neXtProt   Signor 16446428
S244 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 30517763
S257 Phosphorylation P31749 (AKT1) Signor 30517763
T263 Phosphorylation neXtProt   Signor 16446428
T263 Phosphorylation P45983 (MAPK8) neXtProt   Signor 16446428
S273 Phosphorylation neXtProt   Signor 16446428
S273 Phosphorylation P45983 (MAPK8) neXtProt   Signor 16446428
Y343 Phosphorylation PhosphoSitePlus
Y344 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
T385 Phosphorylation PhosphoSitePlus   UniProt 16888620
T385 Phosphorylation Q96BR1 (SGK3) PhosphoSitePlus 16888620
S393 Phosphorylation PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
Y420 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16387660
Y420 Phosphorylation P06241 (FYN) phospho.ELM   PhosphoSitePlus 16387660
K432 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
S450 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 16888620, 17437719
S450 Phosphorylation P17612 (PRKACA) neXtProt 17437719
S450 Phosphorylation Q96BR1 (SGK3) PhosphoSitePlus 16888620
K478 Ubiquitination PhosphoSitePlus
Y495 Phosphorylation PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
T505 Phosphorylation PhosphoSitePlus
Y506 Phosphorylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
Y589 Phosphorylation PhosphoSitePlus
K665 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
S687 Phosphorylation PhosphoSitePlus
K858 Ubiquitination PhosphoSitePlus
K861 Ubiquitination PhosphoSitePlus
K881 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S4 Phosphorylation HPRD 20068231
S10 Phosphorylation HPRD 20068231
S13 Phosphorylation HPRD 20068231
T15 Phosphorylation HPRD 20068231
S161 Phosphorylation PhosphoSitePlus 23435430
S161 Phosphorylation Q13315 (ATM) PhosphoSitePlus 23435430
T222 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 F2 Biomuta [ cosmic ]
T222 P222 Biomuta DOID:4362 / cervical cancer [ icgc ]