iPTMnet Report for Q96IZ6 (METTL2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96IZ6 / MET2A_HUMAN
Protein Name tRNA N(3)-methylcytidine methyltransferase METTL2A
Gene Name Name: METTL2A
Synonyms:METTL2;ORFNames:HSPC266;
Organism Homo sapiens (Human)

PRO ID PR:Q96IZ6
DAG View
PRO Name tRNA N(3)-methylcytidine methyltransferase METTL2A (human)
Definition A tRNA N(3)-methylcytidine methyltransferase METTL2A that is encoded in the genome of human.
Short Label hMETTL2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96IZ6 (METTL2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
S4 Phosphorylation PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K66 Acetylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K113 Methylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
Y293 Phosphorylation PhosphoSitePlus
R348 Methylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S4 F4 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
K120 N120 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R348 H348 Biomuta DOID:363 / uterine cancer [ icgc ]
R348 C348 Biomuta DOID:4159 / skin cancer [ cosmic ]