iPTMnet Report for Q96II8 (LRCH3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96II8 / LRCH3_HUMAN
Protein Name DISP complex protein LRCH3
Gene Name Name: LRCH3
Organism Homo sapiens (Human)

PRO ID PR:Q96II8
DAG View
PRO Name DISP complex protein LRCH3 (human)
Definition A DISP complex protein LRCH3 that is encoded in the genome of human.
Short Label hLRCH3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96II8 (LRCH3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S95 Phosphorylation PhosphoSitePlus
C116 Methylation IEDB 31844290
K153 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
R205 Methylation PhosphoSitePlus
R222 Methylation PhosphoSitePlus
C236 Methylation IEDB 31844290
S255 Phosphorylation PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
S324 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
T329 Phosphorylation PhosphoSitePlus
K344 Acetylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
Y354 Phosphorylation PhosphoSitePlus
Y408 Phosphorylation PhosphoSitePlus
S415 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19367720, 18669648, 23186163, ...24275569
S419 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18847512
S419 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K422 Ubiquitination PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
Y490 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K510 Acetylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K512 Acetylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
S516 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K519 Ubiquitination PhosphoSitePlus
C547 Methylation IEDB 31844290
S582 Phosphorylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
T586 Phosphorylation PhosphoSitePlus
S592 Phosphorylation PhosphoSitePlus
Y595 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
S611 Phosphorylation PhosphoSitePlus   UniProt 23186163
S628 Phosphorylation PhosphoSitePlus   UniProt 23186163
C676 Methylation IEDB 31844290
S707 Phosphorylation PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S324 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
T329 Phosphorylation HPRD 20068231
S415 Phosphorylation HPRD 18669648, 20068231
S419 Phosphorylation HPRD 18669648, 20068231
S516 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K153 I153 Biomuta DOID:1324 / lung cancer [ cosmic ]
K153 T153 Biomuta DOID:1324 / lung cancer [ cosmic ]
R205 I205 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R222 W222 Biomuta DOID:1324 / lung cancer [ cosmic ]
R222 Q222 Biomuta DOID:363 / uterine cancer [ icgc ]
S318 C318 Biomuta DOID:3571 / liver cancer [ cosmic ]
T329 A329 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y354 C354 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S419 L419 Biomuta DOID:1319 / brain cancer [ cosmic ]
K431 T431 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S582 I582 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S592 F592 Biomuta DOID:4159 / skin cancer [ cosmic ]
S592 C592 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S592 T592 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]