Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96I25 / SPF45_HUMAN
Protein Name Splicing factor 45
Gene Name Name: RBM17
Synonyms:SPF45;
Organism Homo sapiens (Human)

PRO ID PR:Q96I25
DAG View
PRO Name splicing factor 45 (human)
Definition A splicing factor 45 that is encoded in the genome of human.
Short Label hRBM17
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96I25 (RBM17) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 22223895
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
K21 Acetylation PhosphoSitePlus   UniProt 19608861
K21 Ubiquitination PhosphoSitePlus
K24 Methylation PhosphoSitePlus
K24 Sumoylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
S48 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 23519612
S48 Phosphorylation P49759 (CLK1) neXtProt   PhosphoSitePlus 23519612
K58 Acetylation PhosphoSitePlus
K58 Methylation PhosphoSitePlus
S62 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 23519612
S62 Phosphorylation P49759 (CLK1) neXtProt   PhosphoSitePlus 23519612
R66 Methylation PhosphoSitePlus
T71 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 23186163, 17081983, ...22615491, 20068231
T71 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 22615491
S85 Phosphorylation PhosphoSitePlus
K129 Acetylation PhosphoSitePlus
S155 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18491316, ...23186163, 17081983, 18767875, 18318008, 19651622, 19367720, 18669648, 19415658, 24275569, 20166139, 17287340, 19690332, 20068231
Y161 Phosphorylation PhosphoSitePlus
S169 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19007248, ...20068231
T179 Phosphorylation HPRD   PhosphoSitePlus 20068231
S180 Phosphorylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S202 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 23519612
S202 Phosphorylation P49759 (CLK1) neXtProt   PhosphoSitePlus 23519612
S204 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 17287340, 23519612
S204 Phosphorylation P49759 (CLK1) neXtProt   PhosphoSitePlus 23519612
Y214 Phosphorylation PhosphoSitePlus
S222 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 20230923, 23519612, ...19691289, 22615491, 19651622, 18669648, 24275569, 18707149, 20068231
S222 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 22615491
S222 Phosphorylation P49759 (CLK1) neXtProt   PhosphoSitePlus 23519612
T224 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18452278, 20068231, ...20230923
S227 Phosphorylation HPRD   PhosphoSitePlus 18452278, 17081983, 20068231, ...20230923
S229 Phosphorylation HPRD   PhosphoSitePlus 17081983
T237 Phosphorylation PhosphoSitePlus   UniProt 23186163
K245 Ubiquitination PhosphoSitePlus
K256 Acetylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
S266 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 23519612
S266 Phosphorylation P49759 (CLK1) neXtProt   PhosphoSitePlus 23519612
R273 Methylation PhosphoSitePlus
K285 Acetylation PhosphoSitePlus
S288 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 23519612
S288 Phosphorylation P49759 (CLK1) neXtProt   PhosphoSitePlus 23519612
S291 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 23519612
S291 Phosphorylation P49759 (CLK1) neXtProt   PhosphoSitePlus 23519612
S293 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
T304 Phosphorylation PhosphoSitePlus
K391 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 Y28 Biomuta DOID:363 / uterine cancer [ tcga ]
S48 G48 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S169 G169 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S180 Y180 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S198 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S229 F229 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R273 C273 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S291 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S293 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]