Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96I15 / SCLY_HUMAN
Protein Name Selenocysteine lyase
Gene Name Name: SCLY
Synonyms:SCL;
Organism Homo sapiens (Human)

PRO ID PR:Q96I15
DAG View
PRO Name selenocysteine lyase (human)
Definition A selenocysteine lyase that is encoded in the genome of human.
Short Label hSCLY
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96I15 (SCLY) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
K24 Ubiquitination PhosphoSitePlus
K31 Ubiquitination PhosphoSitePlus
Y33 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K89 Methylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus   UniProt 20068231
K132 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 V1 Biomuta DOID:1324 / lung cancer [ cosmic ]
S81 N81 Biomuta DOID:1324 / lung cancer [ tcga ]
S129 I129 Biomuta DOID:1324 / lung cancer [ tcga ]
K307 N307 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]