iPTMnet Report for Q96HS1 (PGAM5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96HS1 / PGAM5_HUMAN
Protein Name Serine/threonine-protein phosphatase PGAM5, mitochondrial
Gene Name Name: PGAM5
Organism Homo sapiens (Human)

PRO ID PR:Q96HS1
DAG View
PRO Name serine/threonine-protein phosphatase PGAM5, mitochondrial (human)
Definition A serine/threonine-protein phosphatase PGAM5, mitochondrial that is encoded in the genome of human.
Short Label hPGAM5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96HS1 (PGAM5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K75 Acetylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S87 Phosphorylation PhosphoSitePlus   UniProt 23186163
K88 Acetylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
K116 Acetylation PhosphoSitePlus   UniProt 19608861
T131 Phosphorylation PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K144 Acetylation PhosphoSitePlus   UniProt 19608861
K144 Ubiquitination PhosphoSitePlus
C168 S-Nitrosylation dbSNO 26338901
K169 Ubiquitination PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
K191 Acetylation PhosphoSitePlus   UniProt 19608861
K191 Ubiquitination PhosphoSitePlus
C239 Methylation IEDB 31844290
S253 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S87 A87 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K141 E141 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S171 N171 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K191 R191 Biomuta DOID:2394 / ovarian cancer [ cosmic ]