iPTMnet Report for Q96HC4 (PDLIM5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96HC4 / PDLI5_HUMAN
Protein Name PDZ and LIM domain protein 5
Gene Name Name: PDLIM5
Synonyms:ENH;ORFNames:L9;
Organism Homo sapiens (Human)

PRO ID PR:Q96HC4
DAG View
PRO Name PDZ and LIM domain protein 5 (human)
Definition A PDZ and LIM domain protein 5 that is encoded in the genome of human.
Short Label hPDLIM5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96HC4 (PDLIM5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378, 22223895
S2 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
K89 Sumoylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
T110 O-Glycosylation GlyGen   PhosphoSitePlus 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 32938750, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
T110 Phosphorylation PhosphoSitePlus
S111 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S111 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S115 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 32938750, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
T118 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S119 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S119 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
S134 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S134 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 17287340
S136 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S136 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S137 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S137 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 17287340, ...20068231
T141 O-Glycosylation GlyGen 35138101, 25813380, 30059200, ...31492838, 32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S142 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S147 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
T151 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
T156 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S159 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S162 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S164 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
T170 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
T199 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
T199 Phosphorylation PhosphoSitePlus
T208 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
T208 Phosphorylation PhosphoSitePlus
T210 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S211 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S211 Phosphorylation PhosphoSitePlus
C213 S-Nitrosylation dbSNO 26338901, 22178444
S214 Phosphorylation PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
Y247 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 18083107, 17287340
T255 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus   UniProt 23186163
K261 Acetylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K262 Acetylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
T290 O-Glycosylation GlyGen 31373491
T290 Phosphorylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
S309 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S309 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S313 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S313 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...24275569, 20068231
S318 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S319 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 34846842, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S319 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S322 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
T323 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
S332 Phosphorylation PhosphoSitePlus
S335 O-Glycosylation GlyGen 35138101, 30059200, 31492838, ...32870666, 35289036, 29351928, 22661428, 29237092, 34725712, 31373491, 32119511, 23271734, 32574038, 35132862, 29485866, 30620550, 28657654, 33214551, 30379171, 34065225, 35254053, 34019948, 20068230
T355 Phosphorylation PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S362 Phosphorylation PhosphoSitePlus   UniProt 23186163
S372 Phosphorylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
R375 Methylation PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
Y382 Phosphorylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
T417 Phosphorylation PhosphoSitePlus
C423 S-Nitrosylation dbSNO 22126794
T452 Phosphorylation PhosphoSitePlus
Y455 Phosphorylation PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S119 Phosphorylation HPRD 20068231
Y144 Phosphorylation HPRD   PhosphoSitePlus 16497976
Y148 Phosphorylation HPRD   PhosphoSitePlus 18083107, 17287340, 19901323, ...16497976
S213 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y124 Phosphorylation HPRD 16497976
Y128 Phosphorylation HPRD 18083107, 19901323, 17287340, ...16497976


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S31 C31 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K34 N34 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S111 Y111 Biomuta DOID:363 / uterine cancer [ icgc ]
S115 F115 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T118 N118 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S119 F119 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S134 F134 Biomuta DOID:4159 / skin cancer [ cosmic ]
S136 F136 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ icgc ] DOID:2531 / hematologic cancer [ icgc ]
S142 P142 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S147 L147 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T151 S151 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T156 A156 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S164 P164 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T170 I170 Biomuta DOID:363 / uterine cancer [ icgc ]
T199 P199 Biomuta DOID:10534 / stomach cancer [ cosmic ]
C213 S213 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S214 F214 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S217 A217 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S217 F217 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S228 F228 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S232 N232 Biomuta DOID:4159 / skin cancer [ cosmic ]
S257 I257 Biomuta DOID:1324 / lung cancer [ cosmic ]
S257 G257 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S260 R260 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S260 N260 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S313 Y313 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S335 A335 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T381 A381 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y455 D455 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]