iPTMnet Report for Q96GX5 (MASTL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96GX5 / GWL_HUMAN
Protein Name Serine/threonine-protein kinase greatwall
Gene Name Name: MASTL
Synonyms:GW,GWL,THC2;
Organism Homo sapiens (Human)

PRO ID PR:Q96GX5
DAG View
PRO Name serine/threonine-protein kinase greatwall (human)
Definition A microtubule-associated serine/threonine-protein kinase-like that is encoded in the genome of human.
Short Label hMASTL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96GX5 (MASTL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K9 Ubiquitination PhosphoSitePlus
T17 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
T75 Phosphorylation PhosphoSitePlus
S90 Phosphorylation RLIMS-P 26653855
K158 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
T194 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 26872783, 18669648, 24391510, ...27563826
K199 Ubiquitination PhosphoSitePlus
T207 Phosphorylation PRO   PhosphoSitePlus   RLIMS-P   UniProt 26872783, 20068231
S216 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus   UniProt 20068231
K258 Sumoylation PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K269 Methylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
T274 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S293 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T299 Phosphorylation PhosphoSitePlus
S300 O-Glycosylation GlyGen 23301498, 31492838, 32574038, ...34019948
S303 Phosphorylation PhosphoSitePlus
S311 O-Glycosylation GlyGen 32574038
S311 Phosphorylation PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
S370 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18220336, ...18669648, 20068231
S375 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S376 Phosphorylation PhosphoSitePlus
T380 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S452 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S453 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18669648, 26653855
C465 Methylation IEDB 31844290
K497 Ubiquitination PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
S512 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T514 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K516 Ubiquitination PhosphoSitePlus
T519 Phosphorylation PhosphoSitePlus   UniProt 23186163
S550 Phosphorylation PhosphoSitePlus
S551 Phosphorylation PhosphoSitePlus
S552 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S556 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S597 Phosphorylation PhosphoSitePlus
S598 Phosphorylation PhosphoSitePlus
S602 Phosphorylation IEDB 35494241
T611 Phosphorylation PhosphoSitePlus
T618 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K621 Ubiquitination PhosphoSitePlus
S631 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16964243, 20068231
K634 Ubiquitination PhosphoSitePlus
K644 Acetylation PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
S657 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
S660 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
S668 Phosphorylation PhosphoSitePlus   UniProt 20068231
S671 Phosphorylation PhosphoSitePlus
C685 Methylation IEDB 31844290
T696 Phosphorylation PhosphoSitePlus
T710 Phosphorylation PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
T718 Phosphorylation PhosphoSitePlus   RLIMS-P 27563826
Y720 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T722 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S725 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T741 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   UniProt 18669648
T860 Phosphorylation PhosphoSitePlus
S861 Phosphorylation RLIMS-P 36270968
T868 Phosphorylation PhosphoSitePlus
T873 Phosphorylation PhosphoSitePlus
S875 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26906418, 18669648, 27563826, ...26872783, 20068231
S878 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 23186163, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
S703 Phosphorylation PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
T717 Phosphorylation PhosphoSitePlus
T721 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T194 Phosphorylation HPRD 18669648, 20068231
T207 Phosphorylation HPRD 20068231
S213 Phosphorylation HPRD 20068231
S217 Phosphorylation HPRD 20068231
T222 Phosphorylation HPRD 20068231
S293 Phosphorylation HPRD 18669648
S370 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S375 Phosphorylation HPRD 18669648
S452 Phosphorylation HPRD 18691976, 18669648, 19664995, ...18767875
S453 Phosphorylation HPRD 17322306, 18767875, 18669648, ...19664994, 19664995
S512 Phosphorylation HPRD 18691976, 18669648, 20068231
T514 Phosphorylation HPRD 18669648
T519 Phosphorylation HPRD 20068231
Y548 Phosphorylation HPRD 18691976
S552 Phosphorylation HPRD 18691976, 18669648
S556 Phosphorylation HPRD 18669648
T618 Phosphorylation HPRD 18669648
S631 Phosphorylation HPRD 18669648, 19007248, 20068231
S657 Phosphorylation HPRD 18691976, 20068231
S665 Phosphorylation HPRD 18691976
S668 Phosphorylation HPRD 18691976, 20068231
Y719 Phosphorylation HPRD 18669648
T721 Phosphorylation HPRD 18669648
S724 Phosphorylation HPRD 18669648
T740 Phosphorylation HPRD 18669648
S874 Phosphorylation HPRD 18691976, 18669648, 20068231
S877 Phosphorylation HPRD 18691976, 18669648, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048340 (hMASTL/Phos:1) pT194,pT207,pT741 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K39 R39 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K72 R72 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S90 G90 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S216 I216 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S217 L217 Biomuta DOID:4159 / skin cancer [ cosmic ]
K258 T258 Biomuta DOID:363 / uterine cancer [ cosmic ]
T261 A261 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T261 M261 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
S320 R320 Biomuta DOID:363 / uterine cancer [ icgc ]
S375 N375 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S452 C452 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C465 S465 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K497 R497 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S512 Y512 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S556 C556 Biomuta DOID:1324 / lung cancer [ cosmic ]
S597 F597 Biomuta DOID:1324 / lung cancer [ cosmic ]
S598 C598 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T618 A618 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K634 R634 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K644 Q644 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S665 Y665 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T721 S721 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, cosmic, icgc, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T722 S722 Biomuta DOID:10534 / stomach cancer [ cosmic ]