iPTMnet Report Q96GM8 TOE1

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q96GM8 / TOE1_HUMAN
Protein Name	Target of EGR1 protein 1
Gene Name	Name: TOE1
Organism	Homo sapiens (Human)

PRO ID	PR:Q96GM8 DAG View
PRO Name	target of EGR1 protein 1 (human)
Definition	A target of EGR1 protein 1 that is encoded in the genome of human.
Short Label	hTOE1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q96GM8 (TOE1) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	A2	Acetylation		score1	UniProt	19413330
	S5	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18691976, 21406692, 23186163, ...17081983, 19369195, 24275569, 20068231
	K74	Ubiquitination		score1	PhosphoSitePlus
	S75	O-Glycosylation		score1	GlyGen	30379171, 28510447
	K164	Ubiquitination		score1	PhosphoSitePlus
	T355	Phosphorylation		score1	PhosphoSitePlus
	S358	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
	K368	Ubiquitination		score1	PhosphoSitePlus
	S374	Phosphorylation		score1	PhosphoSitePlus
	K376	Ubiquitination		score1	PhosphoSitePlus
	S420	Phosphorylation		score1	PhosphoSitePlus
	S425	Phosphorylation		score1	PhosphoSitePlus
	S428	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
	K481	Ubiquitination		score1	PhosphoSitePlus
	K489	Ubiquitination		score1	PhosphoSitePlus
	S510	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S5	Phosphorylation		score0	HPRD	19413330, 18691976, 17081983, ...18767875, 20058876, 19007248, 19664995, 19651622, 19415658, 20068231
	T357	Phosphorylation		score0	HPRD	20068231
	S425	Phosphorylation		score0	HPRD	20068231
	S428	Phosphorylation		score0	HPRD	18669648, 20068231

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
A2	T2	Biomuta		DOID:8618 / oral cavity cancer [ cosmic ]
S374	I374	Biomuta		DOID:363 / uterine cancer [ icgc ]
K489	*	Biomuta		DOID:1324 / lung cancer [ cosmic ]