iPTMnet Report for Q96G25 (MED8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96G25 / MED8_HUMAN
Protein Name Mediator of RNA polymerase II transcription subunit 8
Gene Name Name: MED8
Organism Homo sapiens (Human)

PRO ID PR:Q96G25
DAG View
PRO Name mediator of RNA polymerase II transcription subunit 8 (human)
Definition A mediator of RNA polymerase II transcription subunit 8 that is encoded in the genome of human.
Short Label hMED8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96G25 (MED8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Ubiquitination PhosphoSitePlus
C31 Methylation IEDB 31844290
K67 Ubiquitination PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus   UniProt 19369195, 24275569
K112 Sumoylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
K255 Acetylation PhosphoSitePlus
K259 Acetylation PhosphoSitePlus
K259 Methylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S82 Phosphorylation HPRD 20068231, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S82 Phosphorylation HPRD 20068231, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K122 T122 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K259 T259 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y266 C266 Biomuta DOID:363 / uterine cancer [ icgc ]