iPTMnet Report for Q96FS4 (SIPA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96FS4 / SIPA1_HUMAN
Protein Name Signal-induced proliferation-associated protein 1
Gene Name Name: SIPA1
Synonyms:SPA1;
Organism Homo sapiens (Human)

PRO ID PR:Q96FS4
DAG View
PRO Name signal-induced proliferation-associated protein 1 (human)
Definition A signal-induced proliferation-associated protein 1 that is encoded in the genome of human.
Short Label hSIPA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96FS4 (SIPA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R12 Methylation PhosphoSitePlus
R13 Methylation PhosphoSitePlus
K27 Acetylation PhosphoSitePlus
R47 Methylation PhosphoSitePlus
S53 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20058876
S55 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935, 18669648, 20058876
R61 Methylation PhosphoSitePlus
T64 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S67 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 15302935, ...20058876
S74 Phosphorylation HPRD   PhosphoSitePlus 17081983
S148 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus   UniProt 24275569
K226 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus   UniProt 23186163
S314 Phosphorylation PhosphoSitePlus   UniProt 23186163
K316 Ubiquitination PhosphoSitePlus
T323 Phosphorylation HPRD 18452278
K334 Ubiquitination PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
S559 Phosphorylation HPRD   PhosphoSitePlus 20068231
S664 Phosphorylation HPRD   PhosphoSitePlus 20068231
S680 Phosphorylation HPRD   PhosphoSitePlus 20068231
T685 Phosphorylation HPRD   PhosphoSitePlus 20068231
C755 Methylation IEDB 31844290
K805 Ubiquitination PhosphoSitePlus
S817 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
T829 Phosphorylation PhosphoSitePlus
S834 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus
S839 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18767875, ...18452278, 18669648, 20166139, 20068231
S867 Phosphorylation HPRD 17081983
S870 Phosphorylation HPRD 17081983
S873 Phosphorylation PhosphoSitePlus
T875 Phosphorylation HPRD 17081983
T878 Phosphorylation PhosphoSitePlus
S884 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231, 18452278
S886 Phosphorylation PhosphoSitePlus
S888 Phosphorylation PhosphoSitePlus
S901 Phosphorylation PhosphoSitePlus
T906 Phosphorylation PhosphoSitePlus
S908 Phosphorylation PhosphoSitePlus
S912 Phosphorylation PhosphoSitePlus   UniProt 23186163
S956 Phosphorylation PhosphoSitePlus
T962 Phosphorylation HPRD   PhosphoSitePlus 20068231
S965 Phosphorylation PhosphoSitePlus
S1008 Phosphorylation PhosphoSitePlus
K1032 Ubiquitination PhosphoSitePlus
S1036 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R13 Q13 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R13 W13 Biomuta DOID:1319 / brain cancer [ cosmic ]
R47 Q47 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S53 N53 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S53 T53 Biomuta DOID:363 / uterine cancer [ icgc ]
T64 M64 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S74 I74 Biomuta DOID:1324 / lung cancer [ cosmic ]
S182 F182 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ icgc ]
S680 N680 Biomuta DOID:4159 / skin cancer [ cosmic ]
S817 I817 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
T829 N829 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S867 L867 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S965 F965 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]