iPTMnet Report for Q96F86 (EDC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96F86 / EDC3_HUMAN
Protein Name Enhancer of mRNA-decapping protein 3
Gene Name Name: EDC3
Synonyms:LSM16,YJDC,YJEFN2;ORFNames:PP844;
Organism Homo sapiens (Human)

PRO ID PR:Q96F86
DAG View
PRO Name enhancer of mRNA-decapping protein 3 (human)
Definition An enhancer of mRNA-decapping protein 3 that is encoded in the genome of human.
Short Label hEDC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96F86 (EDC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C47 Methylation IEDB 31844290
T60 Phosphorylation PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
S109 O-Glycosylation GlyGen 31373491
S109 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
S125 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18077418, 20068231
S131 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 16964243, ...18077418, 19664994, 19664995, 17322306, 18669648, 24275569, 17287340, 20068231
C137 S-Nitrosylation dbSNO 26338901
S138 Phosphorylation PhosphoSitePlus   UniProt 21406692
K139 Methylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus   UniProt 21406692
R144 Methylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S150 Phosphorylation HPRD   PhosphoSitePlus 20068231
S152 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S154 Phosphorylation IEDB   PhosphoSitePlus 27920218
S161 Phosphorylation P31749 (AKT1) , P31751 (AKT2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 23186163, 18220336, ...20051463, 17322306, 19690332, 20068231
S163 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
T173 Phosphorylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
Y225 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
R234 Methylation PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
T308 Phosphorylation HPRD 20068231
T318 Phosphorylation HPRD 20068231
S386 Phosphorylation HPRD   PhosphoSitePlus 20068231
K387 Ubiquitination PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
Y475 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S109 C109 Biomuta DOID:1612 / breast cancer [ cosmic ]
K119 N119 Biomuta DOID:1324 / lung cancer [ cosmic ]
S131 F131 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S138 * Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S152 F152 Biomuta DOID:1319 / brain cancer [ icgc ]
S161 F161 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S394 F394 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]