iPTMnet Report for Q96EB6 (SIRT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96EB6 / SIR1_HUMAN
Protein Name NAD-dependent protein deacetylase sirtuin-1
Gene Name Name: SIRT1
Synonyms:SIR2L1;
Organism Homo sapiens (Human)

PRO ID PR:Q96EB6
DAG View
PRO Name NAD-dependent protein deacetylase sirtuin-1 (human)
Definition An NAD-dependent protein deacetylase sirtuin-1 that is encoded in the genome of human.
Short Label hSIRT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96EB6 (SIRT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 21406692, 22223895, ...22814378, 20068231
S14 Phosphorylation PhosphoSitePlus   UniProt 19107194, 23186163, 21406692, ...24275569, 20068231
S16 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus   UniProt 19107194
S27 Phosphorylation Q9H2X6 (HIPK2) , Q96RR4 (CAMKK2) , P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 31100089, 23186163, 24275569, ...30205735, 15302935, 19107194, 20027304, 26113041, 18838864, 27991597, 23754392
S47 Phosphorylation P45983 (MAPK8) , Q96RR4 (CAMKK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25386949, 19107194, 23186163, ...16964243, 23754392, 30205735, 15302935, 21406692, 20027304, 23968571, 18669648, 21471201, 21540183, 18838864, 32660255, 27991597, 27542238, 32910941, 20068231, 17081983
S159 Phosphorylation PhosphoSitePlus   UniProt 19107194
S162 Phosphorylation PhosphoSitePlus   UniProt 19107194
S172 Phosphorylation PhosphoSitePlus   UniProt 19107194
S173 Phosphorylation PhosphoSitePlus   UniProt 19107194
K238 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
Y280 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
T344 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus   RLIMS-P+   RLIMS-P 24959379, 30988280, 22728651
Y428 Phosphorylation PhosphoSitePlus
K430 Acetylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
K444 Acetylation PhosphoSitePlus
C490 Methylation IEDB 31844290
K499 Ubiquitination PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
T530 Phosphorylation Q13627 (DYRK1A) , P06493 (CDK1) , P45983 (MAPK8) neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19107194, 20167603, 28549174, ...20027304, 19690332
S535 Phosphorylation PhosphoSitePlus   UniProt 19690332
S538 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
S540 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus   Signor 19107194
T544 Phosphorylation PhosphoSitePlus   UniProt 19107194
S545 Phosphorylation PhosphoSitePlus   UniProt 19107194
S549 O-Glycosylation GlyGen 23301498, 27345396, 29351928, ...29688431, 28510447, 29133780, 32152092
S549 Phosphorylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
S569 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K572 Ubiquitination PhosphoSitePlus
C574 S-Nitrosylation dbSNO 26338901
K578 Acetylation PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
T614 O-Glycosylation GlyGen 23301498, 27345396, 29351928, ...29688431, 28510447, 29133780, 32152092
T614 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
T619 Phosphorylation PhosphoSitePlus
K622 Methylation PhosphoSitePlus
S659 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P   Signor 19236849, 22510409
S661 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P   Signor   UniProt 19236849, 22510409
S669 Phosphorylation PhosphoSitePlus
S682 Phosphorylation Q9H2X6 (HIPK2) PhosphoSitePlus   RLIMS-P 26113041
T719 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 19107194, ...18669648, 19690332
S732 Phosphorylation PhosphoSitePlus
K734 Sumoylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus   UniProt 19107194
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 19413330, 19651622, 20068231
S16 Phosphorylation HPRD 19413330
S26 Phosphorylation HPRD 19651622, 17081983, 20068231
S27 Phosphorylation HPRD 19413330, 19651622, 15302935, ...19664995, 20068231
S47 Phosphorylation HPRD 18767875, 15302935, 19007248, ...19651622, 18669648, 20068231, 17924679
S525 Phosphorylation HPRD 20068231
T530 Phosphorylation HPRD 20068231
S535 Phosphorylation HPRD 20068231
S538 Phosphorylation HPRD 20068231
S539 Phosphorylation HPRD 20068231
T554 Phosphorylation HPRD 20068231
S569 Phosphorylation HPRD 18669648, 20068231
T719 Phosphorylation HPRD 19413330, 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q8N163 (CCAR2) T454 Q96EB6 (SIRT1) unknown eFIP 25361978
Phosphorylation Q8N163 (CCAR2) T454 Q96EB6 (SIRT1) unknown eFIP 30245854
Phosphorylation Q96EB6 (SIRT1) T344 P04637 (TP53) decreased_association eFIP 30988280


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 P14 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S27 F27 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S159 F159 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K314 N314 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S333 L333 Biomuta DOID:363 / uterine cancer [ icgc ]
K430 T430 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S549 F549 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S549 C549 Biomuta DOID:1324 / lung cancer [ cosmic ]
S590 N590 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S669 G669 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S682 I682 Biomuta DOID:9256 / colorectal cancer [ icgc ]