iPTMnet Report for Q96DU7 (ITPKC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96DU7 / IP3KC_HUMAN
Protein Name Inositol-trisphosphate 3-kinase C
Gene Name Name: ITPKC
Synonyms:IP3KC;
Organism Homo sapiens (Human)

PRO ID PR:Q96DU7
DAG View
PRO Name inositol-trisphosphate 3-kinase C (human)
Definition An inositol-trisphosphate 3-kinase C that is encoded in the genome of human.
Short Label hITPKC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96DU7 (ITPKC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R7 Methylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
R30 Methylation PhosphoSitePlus
S84 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus   UniProt 24275569
S190 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus   UniProt 23186163
S348 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
Y398 Phosphorylation PhosphoSitePlus
S404 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y456 Phosphorylation PhosphoSitePlus
Y457 Phosphorylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
T566 Phosphorylation PhosphoSitePlus
K569 Ubiquitination PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S322 I322 Biomuta DOID:363 / uterine cancer [ icgc ]
S348 P348 Biomuta DOID:1612 / breast cancer [ cosmic ]
K579 T579 Biomuta DOID:3571 / liver cancer [ cosmic ]