iPTMnet Report for Q96DF8 (ESS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96DF8 / ESS2_HUMAN
Protein Name Splicing factor ESS-2 homolog
Gene Name Name: ESS2
Synonyms:DGCR13,DGCR14,DGSH,DGSI,ES2;
Organism Homo sapiens (Human)

PRO ID PR:Q96DF8
DAG View
PRO Name splicing factor ESS-2 homolog (human)
Definition A splicing factor ESS-2 homolog that is encoded in the genome of human.
Short Label hESS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96DF8 (ESS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
T3 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163
K22 Ubiquitination PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
T107 Phosphorylation PhosphoSitePlus
T110 Phosphorylation PhosphoSitePlus
T117 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
R129 Methylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
S292 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
T333 Phosphorylation PhosphoSitePlus
T339 Phosphorylation PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
K358 Methylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
T386 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 19664995
K388 Ubiquitination PhosphoSitePlus
S391 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19664995, ...18669648, 20068231
S395 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19664995, ...18669648, 20068231
S403 Phosphorylation PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
K408 Acetylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
R415 Methylation PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
T419 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
R424 Methylation PhosphoSitePlus
T426 Phosphorylation PhosphoSitePlus
K429 Methylation PhosphoSitePlus
T430 O-Glycosylation GlyGen 35132862, 35254053
T430 Phosphorylation PhosphoSitePlus
T437 Phosphorylation PhosphoSitePlus
T439 Phosphorylation PhosphoSitePlus
S440 O-Glycosylation GlyGen 35132862, 30620550, 35254053
S446 O-Glycosylation GlyGen 35132862, 35254053
S446 Phosphorylation PhosphoSitePlus
T450 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
K471 Methylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y43 C43 Biomuta DOID:1612 / breast cancer [ cosmic ]
T104 A104 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T117 I117 Biomuta DOID:4159 / skin cancer [ cosmic ]
K123 * Biomuta DOID:4159 / skin cancer [ cosmic ]
R129 Q129 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
K221 N221 Biomuta DOID:363 / uterine cancer [ icgc ]
S292 Y292 Biomuta DOID:3571 / liver cancer [ cosmic ]
T333 M333 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T405 M405 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R415 Q415 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R415 W415 Biomuta DOID:3571 / liver cancer [ cosmic ]
S417 N417 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R424 C424 Biomuta DOID:4159 / skin cancer [ cosmic ]
S446 C446 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]