iPTMnet Report for Q96D71 (REPS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96D71 / REPS1_HUMAN
Protein Name RalBP1-associated Eps domain-containing protein 1
Gene Name Name: REPS1
Organism Homo sapiens (Human)

PRO ID PR:Q96D71
DAG View
PRO Name RalBP1-associated Eps domain-containing protein 1 (human)
Definition A RalBP1-associated Eps domain-containing protein 1 that is encoded in the genome of human.
Short Label hREPS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96D71 (REPS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K27 Ubiquitination PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S110 Phosphorylation phospho.ELM 18669648, 18220336
S115 Phosphorylation PhosphoSitePlus
Y116 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
S118 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S120 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus
Y126 Phosphorylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus   UniProt 20068231
S145 Phosphorylation PhosphoSitePlus   UniProt 21406692
T148 Phosphorylation PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
S162 Phosphorylation PhosphoSitePlus   UniProt 18669648, 19690332, 18220336
S166 Phosphorylation PhosphoSitePlus   UniProt 18669648, 24275569
S170 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...18669648, 24275569, 19690332
T173 Phosphorylation PhosphoSitePlus   UniProt 19690332, 24275569
S174 Phosphorylation PhosphoSitePlus
T177 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
T258 O-Glycosylation GlyGen 33214551, 31637018, 32938750, ...28411811, 35254053, 34019948, 28657654
S261 O-Glycosylation GlyGen 33214551, 31637018, 28411811, ...35254053, 34019948, 28657654
S261 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
T264 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S273 Phosphorylation PhosphoSitePlus   UniProt 23186163
S274 Phosphorylation PhosphoSitePlus
Y275 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163
S377 Phosphorylation PhosphoSitePlus
Y389 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S392 Phosphorylation PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
S430 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
K462 Ubiquitination PhosphoSitePlus
K471 Methylation PhosphoSitePlus
T473 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus   UniProt 23186163
T478 Phosphorylation PhosphoSitePlus
T481 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus   UniProt 23186163
S489 Phosphorylation PhosphoSitePlus   UniProt 17081983
S500 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
S518 Phosphorylation PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
T539 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus   UniProt 19690332
T544 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S667 Phosphorylation PhosphoSitePlus
T681 O-Glycosylation GlyGen 31373491
S684 O-Glycosylation GlyGen 31373491
S690 O-Glycosylation GlyGen 31373491
T694 Phosphorylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 24275569, ...18318008
T721 Phosphorylation PhosphoSitePlus
T724 Phosphorylation IEDB 35494241
S736 Phosphorylation PhosphoSitePlus
S740 Phosphorylation PhosphoSitePlus   UniProt 20068231
S751 Phosphorylation PhosphoSitePlus
T758 Phosphorylation PhosphoSitePlus
S767 Phosphorylation PhosphoSitePlus
S794 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S401 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y116 Phosphorylation HPRD 15592455
S117 Phosphorylation HPRD 20068231
S118 Phosphorylation HPRD 18669648
Y126 Phosphorylation HPRD 15592455
S143 Phosphorylation HPRD 19651622, 20166139, 20068231
S162 Phosphorylation HPRD 18669648
S166 Phosphorylation HPRD 19413330, 18669648
S170 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19415658
T173 Phosphorylation HPRD 19413330, 18669648, 19415658
S174 Phosphorylation HPRD 18669648, 19415658
S272 Phosphorylation HPRD 19651622, 18691976, 18669648, ...19664994, 20068231
S273 Phosphorylation HPRD 19651622, 18669648, 20068231
S274 Phosphorylation HPRD 20068231
Y275 Phosphorylation HPRD 18669648, 20068231
S307 Phosphorylation HPRD 18669648, 20068231
S390 Phosphorylation HPRD 19664994
S392 Phosphorylation HPRD 19413330, 18452278
T459 Phosphorylation HPRD 19664994
S482 Phosphorylation HPRD 20068231, 18707149
S489 Phosphorylation HPRD 17081983
S534 Phosphorylation HPRD 19413330
S536 Phosphorylation HPRD 19413330, 19651622
T538 Phosphorylation HPRD 19413330
S539 Phosphorylation HPRD 19651622
S557 Phosphorylation HPRD 19651622
S561 Phosphorylation HPRD 19651622, 18088087, 20068231
T567 Phosphorylation HPRD 20068231
S708 Phosphorylation HPRD 19651622, 20166139, 18707149
S739 Phosphorylation HPRD 20068231
S750 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S401 Phosphorylation PhosphoSitePlus
S403 Phosphorylation PhosphoSitePlus
T410 Phosphorylation PhosphoSitePlus
T421 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S104 L104 Biomuta DOID:4159 / skin cancer [ cosmic ]
S117 F117 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S125 L125 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S125 W125 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S127 F127 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S143 F143 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T148 M148 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S162 F162 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y275 S275 Biomuta DOID:1324 / lung cancer [ cosmic ]
S429 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S430 G430 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T459 A459 Biomuta DOID:363 / uterine cancer [ icgc ]
T459 N459 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S500 L500 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S515 N515 Biomuta DOID:4159 / skin cancer [ cosmic ]
S518 C518 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T538 A538 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T538 M538 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T539 A539 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T539 M539 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S556 C556 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S560 L560 Biomuta DOID:363 / uterine cancer [ icgc ]
S667 Y667 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S690 N690 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S708 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S709 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T721 K721 Biomuta DOID:3571 / liver cancer [ cosmic ]
T724 A724 Biomuta DOID:363 / uterine cancer [ icgc ]
T724 M724 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, icgc ] DOID:4159 / skin cancer [ cosmic, icgc, cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc, cosmic ] DOID:9256 / colorectal cancer [ cosmic ]