iPTMnet Report for Q96D31 (ORAI1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96D31 / CRCM1_HUMAN
Protein Name Calcium release-activated calcium channel protein 1
Gene Name Name: ORAI1
Synonyms:CRACM1,TMEM142A;
Organism Homo sapiens (Human)

PRO ID PR:Q96D31
DAG View
PRO Name calcium release-activated calcium channel protein 1 (human)
Definition A calcium release-activated calcium channel protein 1 that is encoded in the genome of human.
Short Label hORAI1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96D31 (ORAI1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
S27 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20534587, 31652779, 31036819
S27 Phosphorylation P05771 (PRKCB) neXtProt   PhosphoSitePlus   Signor 20534587
S30 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20534587, 31652779, 31036819
S30 Phosphorylation P05771 (PRKCB) neXtProt   PhosphoSitePlus   Signor 20534587
S34 Phosphorylation PhosphoSitePlus   RLIMS-P 26269433, 31652779, 31036819, ...33076541
S34 Phosphorylation Q13976 (PRKG1) PhosphoSitePlus 26269433
S65 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
N223 N-Glycosylation GlyGen   UniProt 26956484
T295 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S298 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y300 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S65 Phosphorylation HPRD 18578522
T295 Phosphorylation HPRD 18669648, 20068231
S298 Phosphorylation HPRD 18669648


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96D31 (ORAI1) S30 P40145 (ADCY8) unknown eFIP 31652779


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 R34 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y300 H300 Biomuta DOID:1612 / breast cancer [ cosmic ]