iPTMnet Report for Q96CX2 (KCTD12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96CX2 / KCD12_HUMAN
Protein Name BTB/POZ domain-containing protein KCTD12
Gene Name Name: KCTD12
Synonyms:C13orf2,KIAA1778,PFET1;
Organism Homo sapiens (Human)

PRO ID PR:Q96CX2
DAG View
PRO Name BTB/POZ domain-containing protein KCTD12 (human)
Definition A BTB/POZ domain-containing protein KCTD12 that is encoded in the genome of human.
Short Label hKCTD12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96CX2 (KCTD12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
Y91 Phosphorylation PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus   UniProt 24275569
S171 Phosphorylation HPRD   PhosphoSitePlus 19413330
S176 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18452278
T178 Phosphorylation HPRD   PhosphoSitePlus 18452278
S183 Phosphorylation HPRD   PhosphoSitePlus 18452278
S185 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 18578522, 17287340, ...17081983, 28869606, 19651622, 18669648, 20166139, 20068231
S187 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 19413330, 17525332, 17287340, ...28869606, 18578522, 18669648, 20166139, 15345747, 20068231
T196 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 20166139, 17287340
S198 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 17525332, 17287340, ...20166139
S200 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 19413330, 17287340, 28869606, ...20166139, 20068231
S204 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20166139, 17287340
S207 Phosphorylation PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
K229 Acetylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
S243 Phosphorylation O14965 (AURKA) HPRD   PhosphoSitePlus   RLIMS-P   Signor 28869606, 20068231
K246 Ubiquitination PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
R257 Methylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96CX2 (KCTD12) S243 P06493 (CDK1) unknown eFIP 28869606
Phosphorylation Q96CX2 (KCTD12) S243 P30305 (CDC25B) unknown eFIP 28869606


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y91 H91 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T196 A196 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K229 R229 Biomuta DOID:363 / uterine cancer [ icgc ]