iPTMnet Report for Q96CV9 (OPTN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96CV9 / OPTN_HUMAN
Protein Name Optineurin
Gene Name Name: OPTN
Synonyms:FIP2;
Organism Homo sapiens (Human)

PRO ID PR:Q96CV9
DAG View
PRO Name optineurin (human)
Definition An optineurin that is encoded in the genome of human.
Short Label hOPTN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96CV9 (OPTN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
K154 Ubiquitination PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S177 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 33692357, 21617041, 26365381, ...30679426, 23186163, 27035970, 22365832, 18307994, 26376340, 21862579, 27247382, 32296703, 24275569, 33893090, 30083281, 25923723
S177 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 22365832
S177 Phosphorylation Q9UHD2 (TBK1) neXtProt   PhosphoSitePlus 21617041, 26365381, 26376340, ...18307994, 21862579
S191 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus   UniProt 24275569
T202 Phosphorylation PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
S206 O-Glycosylation GlyGen 30379171, 31637018
S206 Phosphorylation PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
S212 O-Glycosylation GlyGen 30379171, 31637018
K213 Ubiquitination PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S234 Phosphorylation PhosphoSitePlus
K333 Acetylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
S342 Phosphorylation PhosphoSitePlus   UniProt 24275569
S346 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
K453 Acetylation PhosphoSitePlus
S473 Phosphorylation PhosphoSitePlus   RLIMS-P+   RLIMS-P 33893090, 26365381, 31247202, ...27035970
S473 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus   RLIMS-P+ 26365381, 27035970
K489 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
S513 Phosphorylation PhosphoSitePlus   RLIMS-P 26365381, 27035970, 21862579
S513 Phosphorylation O14920 (IKBKB) PhosphoSitePlus 21862579
S513 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus 26365381
S519 Phosphorylation PhosphoSitePlus
T525 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S526 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 32385243, 18669648, 23186163
S528 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y533 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S170 Phosphorylation HPRD 19651622, 17081983
S171 Phosphorylation HPRD 19651622, 17081983
S173 Phosphorylation HPRD 19651622, 17081983
S174 Phosphorylation HPRD 19651622, 17081983
S177 Phosphorylation HPRD 19651622, 20166139, 19664994, ...18212344
S342 Phosphorylation HPRD 20166139
T525 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18452278
S526 Phosphorylation HPRD 19651622, 18669648, 20068231, ...18707149
S528 Phosphorylation HPRD 18767875, 18669648, 20058876


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P61026 (RAB10) T73 Q96CV9 (OPTN) increased_association eFIP 30945962
Phosphorylation Q96CV9 (OPTN) S177 Q9UHD2 (TBK1) unknown eFIP 25923723
Phosphorylation Q96CV9 (OPTN) S473 Q9H492 (MAP1LC3A) increased_association eFIP 33893090


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 I15 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K154 N154 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T209 M209 Biomuta DOID:363 / uterine cancer [ icgc ]
S346 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K435 E435 Biomuta DOID:1324 / lung cancer [ cosmic ]
K489 N489 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]