iPTMnet Report for Q96C36 (PYCR2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96C36 / P5CR2_HUMAN
Protein Name Pyrroline-5-carboxylate reductase 2
Gene Name Name: PYCR2
Organism Homo sapiens (Human)

PRO ID PR:Q96C36
DAG View
PRO Name pyrroline-5-carboxylate reductase 2 (human)
Definition A pyrroline-5-carboxylate reductase 2 that is encoded in the genome of human.
Short Label hPYCR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96C36 (PYCR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
Y13 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S33 O-Glycosylation GlyGen 33465208
S33 Phosphorylation PhosphoSitePlus
S34 O-Glycosylation GlyGen 33465208
S34 Phosphorylation PhosphoSitePlus
T41 O-Glycosylation GlyGen 36240223, 28510447, 35138101, ...33465208, 34229054
T41 Phosphorylation PhosphoSitePlus
S43 O-Glycosylation GlyGen 36240223, 28510447, 35138101, ...33465208, 34229054
K47 Acetylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
C232 Methylation IEDB 31844290
S233 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
T301 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S303 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 18847512
S304 Phosphorylation P06493 (CDK1) , P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18847512, 18234856, 18669648, 20068231
K307 Ubiquitination PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y13 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
S252 F252 Biomuta [ cosmic ]
T265 A265 Biomuta DOID:1324 / lung cancer [ cosmic ]
K276 N276 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S294 F294 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T296 I296 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S303 F303 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S304 N304 Biomuta DOID:1319 / brain cancer [ cosmic ]