iPTMnet Report for Q96C24 (SYTL4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96C24 / SYTL4_HUMAN
Protein Name Synaptotagmin-like protein 4
Gene Name Name: SYTL4
Organism Homo sapiens (Human)

PRO ID PR:Q96C24
DAG View
PRO Name synaptotagmin-like protein 4 (human)
Definition A synaptotagmin-like protein 4 that is encoded in the genome of human.
Short Label hSYTL4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96C24 (SYTL4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K47 Ubiquitination PhosphoSitePlus
S74 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
K123 Ubiquitination PhosphoSitePlus
R130 Methylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
R137 Methylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
S199 Phosphorylation phospho.ELM 18669648
S201 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18088087
S204 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18088087
T206 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
S217 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K220 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus   UniProt 23186163
S231 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus   UniProt 24275569
S289 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 18669648, 23186163
S294 Phosphorylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
Y366 Phosphorylation PhosphoSitePlus
Y396 Phosphorylation PhosphoSitePlus
S488 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 23186163
K510 Ubiquitination PhosphoSitePlus
T511 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus
T546 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
Y554 Phosphorylation PhosphoSitePlus
S563 Phosphorylation PhosphoSitePlus
T567 Phosphorylation PhosphoSitePlus
Y649 Phosphorylation PhosphoSitePlus
S652 Phosphorylation PhosphoSitePlus
K666 Acetylation PhosphoSitePlus
K668 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S74 Phosphorylation HPRD 18088087
S199 Phosphorylation HPRD 18669648
S201 Phosphorylation HPRD 18669648, 18088087, 18452278
S204 Phosphorylation HPRD 18669648, 18088087, 18452278
S217 Phosphorylation HPRD 18669648
S289 Phosphorylation HPRD 18669648, 18088087
S488 Phosphorylation HPRD 18088087


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R130 S130 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
R130 C130 Biomuta [ cosmic ]
R137 G137 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R137 S137 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K177 N177 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S180 N180 Biomuta DOID:1324 / lung cancer [ cosmic ]
S213 C213 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S231 F231 Biomuta DOID:4159 / skin cancer [ cosmic ]
S289 F289 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S340 N340 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S520 N520 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y649 * Biomuta DOID:1324 / lung cancer [ cosmic ]