iPTMnet Report for Q96C19 (EFHD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96C19 / EFHD2_HUMAN
Protein Name EF-hand domain-containing protein D2
Gene Name Name: EFHD2
Synonyms:SWS1;
Organism Homo sapiens (Human)

PRO ID PR:Q96C19
DAG View
PRO Name EF-hand domain-containing protein D2 (human)
Definition An EF-hand domain-containing protein D2 that is encoded in the genome of human.
Short Label hEFHD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96C19 (EFHD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 20068231
T3 Phosphorylation PhosphoSitePlus
K9 Acetylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
S11 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
T24 Phosphorylation PhosphoSitePlus
S74 Phosphorylation P06493 (CDK1) , P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 17081983, ...24275569, 17287340, 18212344, 16964243, 18767875, 18847512, 18234856, 19664994, 19690332, 17322306, 18669648, 20058876, 23186163, 19415658, 20068231, 17924679
S76 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 18767875, ...18847512, 17322306, 18669648, 24275569, 19415658, 20068231
Y83 Phosphorylation PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K102 Acetylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K147 Methylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
C172 S-Nitrosylation dbSNO 22178444
S183 Phosphorylation PhosphoSitePlus   RLIMS-P 28011271
K188 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S204 Phosphorylation HPRD   PhosphoSitePlus 20068231
K233 Acetylation PhosphoSitePlus   UniProt 19608861
K233 Methylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
K240 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K9 R9 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T24 A24 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K87 M87 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y104 D104 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K147 N147 Biomuta DOID:3571 / liver cancer [ cosmic ]
K159 E159 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]