Protein Information

Cytoscape View


UniProt AC / UniProt ID Q96BY9 / SARAF_HUMAN
Protein Name Store-operated calcium entry-associated regulatory factor precursor
Gene Name Name: SARAF
Synonyms:TMEM66,XTP3;ORFNames:HSPC035,NPD003,PSEC0019,UNQ1967/PRO4499;
Organism Homo sapiens (Human)

PRO ID PR:Q96BY9
DAG View
PRO Name store-operated calcium entry-associated regulatory factor (human)
Definition A store-operated calcium entry-associated regulatory factor that is encoded in the genome of human.
Short Label hSARAF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q96BY9 (SARAF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K43 Ubiquitination PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
T265 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S167 Phosphorylation HPRD 19413330
S170 Phosphorylation HPRD 19413330
T178 Phosphorylation HPRD 19413330
Y190 Phosphorylation HPRD 19413330


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q13586 (STIM1) Y316 Q96BY9 (SARAF) unknown eFIP 30975919


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y190 H190 Biomuta DOID:1115 / sarcoma [ icgc, tcga ]
T265 I265 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S323 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]